Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.

HeLa cells in culture do not accumulate ascorbic acid unless ascorbic acid or dehydroascorbic acid is available in the medium. Collagen peptidase corresponding to the activity found in the invasive zone of tumours, and acid phosphatase, in HeLa cells cultured under normal conditions, are unaffected...

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Detalles Bibliográficos
Autores principales: Boggust, W. A., McGauley, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009684/
https://www.ncbi.nlm.nih.gov/pubmed/210778
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author Boggust, W. A.
McGauley, H.
author_facet Boggust, W. A.
McGauley, H.
author_sort Boggust, W. A.
collection PubMed
description HeLa cells in culture do not accumulate ascorbic acid unless ascorbic acid or dehydroascorbic acid is available in the medium. Collagen peptidase corresponding to the activity found in the invasive zone of tumours, and acid phosphatase, in HeLa cells cultured under normal conditions, are unaffected by ascorbic acid, but are reduced in cells deprived of carbohydrate. These reduced collagen-peptidase levels, but not acid phosphatase, are restored to the values of normal HeLa cells by ascorbic acid. The relevance of these findings is considered in the context of tumour growth and spread.
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spelling pubmed-20096842009-09-10 Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures. Boggust, W. A. McGauley, H. Br J Cancer Research Article HeLa cells in culture do not accumulate ascorbic acid unless ascorbic acid or dehydroascorbic acid is available in the medium. Collagen peptidase corresponding to the activity found in the invasive zone of tumours, and acid phosphatase, in HeLa cells cultured under normal conditions, are unaffected by ascorbic acid, but are reduced in cells deprived of carbohydrate. These reduced collagen-peptidase levels, but not acid phosphatase, are restored to the values of normal HeLa cells by ascorbic acid. The relevance of these findings is considered in the context of tumour growth and spread. Nature Publishing Group 1978-07 /pmc/articles/PMC2009684/ /pubmed/210778 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Boggust, W. A.
McGauley, H.
Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.
title Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.
title_full Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.
title_fullStr Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.
title_full_unstemmed Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.
title_short Ascorbic acid and dehydroascorbic acid in HeLa cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.
title_sort ascorbic acid and dehydroascorbic acid in hela cells: their effect on the collagen-peptidase activity of glucose-deficient cultures.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009684/
https://www.ncbi.nlm.nih.gov/pubmed/210778
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