Morphological study of the ovaries of leukaemic children.

The ovaries of leukaemic children were studied in 31 specimens obtained at autopsy. Twenty-eight ovaries from normal children of the same age who died from misadventure served as control. All ovaries from normal childred showed follicle growth and contained several large antral follicles. Follicle d...

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Autores principales: Himelstein-Braw, R., Peters, H., Faber, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009696/
https://www.ncbi.nlm.nih.gov/pubmed/687521
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author Himelstein-Braw, R.
Peters, H.
Faber, M.
author_facet Himelstein-Braw, R.
Peters, H.
Faber, M.
author_sort Himelstein-Braw, R.
collection PubMed
description The ovaries of leukaemic children were studied in 31 specimens obtained at autopsy. Twenty-eight ovaries from normal children of the same age who died from misadventure served as control. All ovaries from normal childred showed follicle growth and contained several large antral follicles. Follicle development was inhibited in all ovaries of leukaemic children; 22% showed no follicle growth (quiescent ovaries), and in the ovaries in which there was follicle development, the number and size of antral follicles was significantly smaller than in the control. All children had been treated with cytotoxic drugs, the duration of the treatment being correlated with the stage of ovarian development. The ovaries of children treated for only 1 week were near-normal, while those treated for more than 2 months showed inhibition of follicle growth. It is argued that the disturbance in follicle development is an effect of the cytotoxic drugs, and not an effect of the disease itself. IMAGES:
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spelling pubmed-20096962009-09-10 Morphological study of the ovaries of leukaemic children. Himelstein-Braw, R. Peters, H. Faber, M. Br J Cancer Research Article The ovaries of leukaemic children were studied in 31 specimens obtained at autopsy. Twenty-eight ovaries from normal children of the same age who died from misadventure served as control. All ovaries from normal childred showed follicle growth and contained several large antral follicles. Follicle development was inhibited in all ovaries of leukaemic children; 22% showed no follicle growth (quiescent ovaries), and in the ovaries in which there was follicle development, the number and size of antral follicles was significantly smaller than in the control. All children had been treated with cytotoxic drugs, the duration of the treatment being correlated with the stage of ovarian development. The ovaries of children treated for only 1 week were near-normal, while those treated for more than 2 months showed inhibition of follicle growth. It is argued that the disturbance in follicle development is an effect of the cytotoxic drugs, and not an effect of the disease itself. IMAGES: Nature Publishing Group 1978-07 /pmc/articles/PMC2009696/ /pubmed/687521 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Himelstein-Braw, R.
Peters, H.
Faber, M.
Morphological study of the ovaries of leukaemic children.
title Morphological study of the ovaries of leukaemic children.
title_full Morphological study of the ovaries of leukaemic children.
title_fullStr Morphological study of the ovaries of leukaemic children.
title_full_unstemmed Morphological study of the ovaries of leukaemic children.
title_short Morphological study of the ovaries of leukaemic children.
title_sort morphological study of the ovaries of leukaemic children.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009696/
https://www.ncbi.nlm.nih.gov/pubmed/687521
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AT petersh morphologicalstudyoftheovariesofleukaemicchildren
AT faberm morphologicalstudyoftheovariesofleukaemicchildren

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