Effect of an implanted Walker tumour on metabolism of folic acid in the rat.

The metabolism of 2-[14C] folic acid has been studied in rats with an implanted Walker 256 tumour and in a closely matched group of controls. In animals with tumours, more of the labelled folic acid is converted to 10-formyltetrahydrofolate and 10-formylfolate than in normal animals. No 5-methyltetr...

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Detalles Bibliográficos
Autores principales: Barford, P. A., Blair, J. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009699/
https://www.ncbi.nlm.nih.gov/pubmed/687509
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author Barford, P. A.
Blair, J. A.
author_facet Barford, P. A.
Blair, J. A.
author_sort Barford, P. A.
collection PubMed
description The metabolism of 2-[14C] folic acid has been studied in rats with an implanted Walker 256 tumour and in a closely matched group of controls. In animals with tumours, more of the labelled folic acid is converted to 10-formyltetrahydrofolate and 10-formylfolate than in normal animals. No 5-methyltetrahydrofolate could be detected in tumour tissue, or in the livers of tumour-bearing animals. When a mixture of 2-[14C]- and 3',5',9-[3H]-folic acid is given to tumour-bearing rats a similar pattern of metabolites is found. There is apparenly less scission of the folate molecule in tumour-bearing rats than in normal rats.
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spelling pubmed-20096992009-09-10 Effect of an implanted Walker tumour on metabolism of folic acid in the rat. Barford, P. A. Blair, J. A. Br J Cancer Research Article The metabolism of 2-[14C] folic acid has been studied in rats with an implanted Walker 256 tumour and in a closely matched group of controls. In animals with tumours, more of the labelled folic acid is converted to 10-formyltetrahydrofolate and 10-formylfolate than in normal animals. No 5-methyltetrahydrofolate could be detected in tumour tissue, or in the livers of tumour-bearing animals. When a mixture of 2-[14C]- and 3',5',9-[3H]-folic acid is given to tumour-bearing rats a similar pattern of metabolites is found. There is apparenly less scission of the folate molecule in tumour-bearing rats than in normal rats. Nature Publishing Group 1978-07 /pmc/articles/PMC2009699/ /pubmed/687509 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Barford, P. A.
Blair, J. A.
Effect of an implanted Walker tumour on metabolism of folic acid in the rat.
title Effect of an implanted Walker tumour on metabolism of folic acid in the rat.
title_full Effect of an implanted Walker tumour on metabolism of folic acid in the rat.
title_fullStr Effect of an implanted Walker tumour on metabolism of folic acid in the rat.
title_full_unstemmed Effect of an implanted Walker tumour on metabolism of folic acid in the rat.
title_short Effect of an implanted Walker tumour on metabolism of folic acid in the rat.
title_sort effect of an implanted walker tumour on metabolism of folic acid in the rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009699/
https://www.ncbi.nlm.nih.gov/pubmed/687509
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AT blairja effectofanimplantedwalkertumouronmetabolismoffolicacidintherat

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