Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.

For the first time, change in the proton longitudinal relaxation times (T1) of rat tissues has been examined throughout the whole process of azo-dye hepatocarcinogenesis. Two maxima of the T1 values were observed for liver, on Day 60 and after Day 120, and these changes correlated well with the chan...

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Detalles Bibliográficos
Autores principales: Kodama, M., Ohki, T., Saitô, H., Nagata, C., Tagashira, Y.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009704/
https://www.ncbi.nlm.nih.gov/pubmed/698037
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author Kodama, M.
Ohki, T.
Saitô, H.
Nagata, C.
Tagashira, Y.
author_facet Kodama, M.
Ohki, T.
Saitô, H.
Nagata, C.
Tagashira, Y.
author_sort Kodama, M.
collection PubMed
description For the first time, change in the proton longitudinal relaxation times (T1) of rat tissues has been examined throughout the whole process of azo-dye hepatocarcinogenesis. Two maxima of the T1 values were observed for liver, on Day 60 and after Day 120, and these changes correlated well with the changes in water content. The first peak was ascribed to the immature hepatocytes of hyperplastic nodules, and the second peak to the developed hepatoma cells. The significance of the change in T1 values as a preneoplastic change is discussed.
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spelling pubmed-20097042009-09-10 Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis. Kodama, M. Ohki, T. Saitô, H. Nagata, C. Tagashira, Y. Br J Cancer Research Article For the first time, change in the proton longitudinal relaxation times (T1) of rat tissues has been examined throughout the whole process of azo-dye hepatocarcinogenesis. Two maxima of the T1 values were observed for liver, on Day 60 and after Day 120, and these changes correlated well with the changes in water content. The first peak was ascribed to the immature hepatocytes of hyperplastic nodules, and the second peak to the developed hepatoma cells. The significance of the change in T1 values as a preneoplastic change is discussed. Nature Publishing Group 1978-08 /pmc/articles/PMC2009704/ /pubmed/698037 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kodama, M.
Ohki, T.
Saitô, H.
Nagata, C.
Tagashira, Y.
Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
title Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
title_full Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
title_fullStr Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
title_full_unstemmed Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
title_short Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
title_sort biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009704/
https://www.ncbi.nlm.nih.gov/pubmed/698037
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AT nagatac biphasicchangeofprotonmagneticrelaxationtimesduringazodyehepatocarcinogenesis
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