Tumour-necrosis factor from the rabbit. II. Production by monocytes.

Mononuclear cells from normal rabbit blood were cytotoxic to a number of cell lines in vitro. The cytotoxic cells were contained in the monocyte-enriched fraction adherent to plastic. Supernatants of the monocyte-enriched fraction had the same cytotoxic specificity as the parent cells. The cytotoxic...

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Detalles Bibliográficos
Autor principal: Matthews, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009719/
https://www.ncbi.nlm.nih.gov/pubmed/698047
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author Matthews, N.
author_facet Matthews, N.
author_sort Matthews, N.
collection PubMed
description Mononuclear cells from normal rabbit blood were cytotoxic to a number of cell lines in vitro. The cytotoxic cells were contained in the monocyte-enriched fraction adherent to plastic. Supernatants of the monocyte-enriched fraction had the same cytotoxic specificity as the parent cells. The cytotoxic factor precipitated in 50% saturated ammonium sulphate solution and on gel filtration was heterogeneous with a mol.-wt. range of 30--50,000 u. On the basis of specificity and molecular characteristics, this cytotoxic factor closely resembles rabbit tumour-necrosis factor (TNF) suggesting that TNF or a closely related factor is a normal product of mononuclear phagocytes.
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spelling pubmed-20097192009-09-10 Tumour-necrosis factor from the rabbit. II. Production by monocytes. Matthews, N. Br J Cancer Research Article Mononuclear cells from normal rabbit blood were cytotoxic to a number of cell lines in vitro. The cytotoxic cells were contained in the monocyte-enriched fraction adherent to plastic. Supernatants of the monocyte-enriched fraction had the same cytotoxic specificity as the parent cells. The cytotoxic factor precipitated in 50% saturated ammonium sulphate solution and on gel filtration was heterogeneous with a mol.-wt. range of 30--50,000 u. On the basis of specificity and molecular characteristics, this cytotoxic factor closely resembles rabbit tumour-necrosis factor (TNF) suggesting that TNF or a closely related factor is a normal product of mononuclear phagocytes. Nature Publishing Group 1978-08 /pmc/articles/PMC2009719/ /pubmed/698047 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Matthews, N.
Tumour-necrosis factor from the rabbit. II. Production by monocytes.
title Tumour-necrosis factor from the rabbit. II. Production by monocytes.
title_full Tumour-necrosis factor from the rabbit. II. Production by monocytes.
title_fullStr Tumour-necrosis factor from the rabbit. II. Production by monocytes.
title_full_unstemmed Tumour-necrosis factor from the rabbit. II. Production by monocytes.
title_short Tumour-necrosis factor from the rabbit. II. Production by monocytes.
title_sort tumour-necrosis factor from the rabbit. ii. production by monocytes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009719/
https://www.ncbi.nlm.nih.gov/pubmed/698047
work_keys_str_mv AT matthewsn tumournecrosisfactorfromtherabbitiiproductionbymonocytes

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