Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.

Extracts of ovine squamous-cell carcinoma (OSCC) prepared by different procedures, were injected at varying concentrations into 184 tumour-bearing sheep. At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined. Extracts of OSCC containing...

Descripción completa

Detalles Bibliográficos
Autores principales: Jun, M. H., Johnson, R. H., Maguire, D. J., Hopkins, P. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009732/
https://www.ncbi.nlm.nih.gov/pubmed/708569
_version_ 1782136175594569728
author Jun, M. H.
Johnson, R. H.
Maguire, D. J.
Hopkins, P. S.
author_facet Jun, M. H.
Johnson, R. H.
Maguire, D. J.
Hopkins, P. S.
author_sort Jun, M. H.
collection PubMed
description Extracts of ovine squamous-cell carcinoma (OSCC) prepared by different procedures, were injected at varying concentrations into 184 tumour-bearing sheep. At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined. Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development. Extracts of foetal sheep skin at the 3mg-protein level produced significant enhancement and metastasis. The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment. IMAGES:
format Text
id pubmed-2009732
institution National Center for Biotechnology Information
language English
publishDate 1978
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20097322009-09-10 Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma. Jun, M. H. Johnson, R. H. Maguire, D. J. Hopkins, P. S. Br J Cancer Research Article Extracts of ovine squamous-cell carcinoma (OSCC) prepared by different procedures, were injected at varying concentrations into 184 tumour-bearing sheep. At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined. Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development. Extracts of foetal sheep skin at the 3mg-protein level produced significant enhancement and metastasis. The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment. IMAGES: Nature Publishing Group 1978-09 /pmc/articles/PMC2009732/ /pubmed/708569 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jun, M. H.
Johnson, R. H.
Maguire, D. J.
Hopkins, P. S.
Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.
title Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.
title_full Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.
title_fullStr Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.
title_full_unstemmed Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.
title_short Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.
title_sort enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009732/
https://www.ncbi.nlm.nih.gov/pubmed/708569
work_keys_str_mv AT junmh enhancementandmetastasisafterimmunotherapyofovinesquamouscellcarcinoma
AT johnsonrh enhancementandmetastasisafterimmunotherapyofovinesquamouscellcarcinoma
AT maguiredj enhancementandmetastasisafterimmunotherapyofovinesquamouscellcarcinoma
AT hopkinsps enhancementandmetastasisafterimmunotherapyofovinesquamouscellcarcinoma

Ejemplares similares