Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.

The hypoxic cell sensitizer Misonidazole (Ro-07-0582) induces oncogenic transformations in the C3H/10T1/2 mouse embryo cell line cultured in vitro. A drug concentration of 0.4 mM applied to aerated cells for 3 or 6 days results in a transformation rate comparable to that observed following an X-ray...

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Detalles Bibliográficos
Autores principales: Miller, R. C., Hall, E. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009745/
https://www.ncbi.nlm.nih.gov/pubmed/708572
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author Miller, R. C.
Hall, E. J.
author_facet Miller, R. C.
Hall, E. J.
author_sort Miller, R. C.
collection PubMed
description The hypoxic cell sensitizer Misonidazole (Ro-07-0582) induces oncogenic transformations in the C3H/10T1/2 mouse embryo cell line cultured in vitro. A drug concentration of 0.4 mM applied to aerated cells for 3 or 6 days results in a transformation rate comparable to that observed following an X-ray dose of 1 Gray. A higher drug concentration of 6.0 mM is equivalent to 4 Gy. The combination of Misonidazole and X-rays produces a significant increase in the frequency of transformation over either drug or radiation alone, but the data are equivocal on the question of additivity vs synergism. IMAGES:
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spelling pubmed-20097452009-09-10 Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole. Miller, R. C. Hall, E. J. Br J Cancer Research Article The hypoxic cell sensitizer Misonidazole (Ro-07-0582) induces oncogenic transformations in the C3H/10T1/2 mouse embryo cell line cultured in vitro. A drug concentration of 0.4 mM applied to aerated cells for 3 or 6 days results in a transformation rate comparable to that observed following an X-ray dose of 1 Gray. A higher drug concentration of 6.0 mM is equivalent to 4 Gy. The combination of Misonidazole and X-rays produces a significant increase in the frequency of transformation over either drug or radiation alone, but the data are equivocal on the question of additivity vs synergism. IMAGES: Nature Publishing Group 1978-09 /pmc/articles/PMC2009745/ /pubmed/708572 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Miller, R. C.
Hall, E. J.
Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
title Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
title_full Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
title_fullStr Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
title_full_unstemmed Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
title_short Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
title_sort oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009745/
https://www.ncbi.nlm.nih.gov/pubmed/708572
work_keys_str_mv AT millerrc oncogenictransformationinvitrobythehypoxiccellsensitizermisonidazole
AT hallej oncogenictransformationinvitrobythehypoxiccellsensitizermisonidazole

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