Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.

The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared wi...

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Detalles Bibliográficos
Autores principales: Roberts, M. M., Rubens, R. D., King, R. J., Hawkins, R. A., Millis, R. R., Hayward, J. L., Forrest, A. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009752/
https://www.ncbi.nlm.nih.gov/pubmed/708575
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author Roberts, M. M.
Rubens, R. D.
King, R. J.
Hawkins, R. A.
Millis, R. R.
Hayward, J. L.
Forrest, A. P.
author_facet Roberts, M. M.
Rubens, R. D.
King, R. J.
Hawkins, R. A.
Millis, R. R.
Hayward, J. L.
Forrest, A. P.
author_sort Roberts, M. M.
collection PubMed
description The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared with only 3/39 without ER. It was found that site of biopsy did not influence the result, but tumour content of the tissue sample was significantly related to the presence of receptors. The organizational problems of such a study are discussed.
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spelling pubmed-20097522009-09-10 Oestrogen receptors and the response to endocrine therapy in advanced breast cancer. Roberts, M. M. Rubens, R. D. King, R. J. Hawkins, R. A. Millis, R. R. Hayward, J. L. Forrest, A. P. Br J Cancer Research Article The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared with only 3/39 without ER. It was found that site of biopsy did not influence the result, but tumour content of the tissue sample was significantly related to the presence of receptors. The organizational problems of such a study are discussed. Nature Publishing Group 1978-09 /pmc/articles/PMC2009752/ /pubmed/708575 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Roberts, M. M.
Rubens, R. D.
King, R. J.
Hawkins, R. A.
Millis, R. R.
Hayward, J. L.
Forrest, A. P.
Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
title Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
title_full Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
title_fullStr Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
title_full_unstemmed Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
title_short Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
title_sort oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009752/
https://www.ncbi.nlm.nih.gov/pubmed/708575
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