Growth and transplantability of clonally related tumorigenic murine cell lines.

A malignant cell line derived from the s.c. inoculation of Adenovirus 12 into a CBA mouse has been isolated in vitro, cloned, and within 10 passages the clones have been investigated for their karyotype, morphology, growth rate, saturation density and response to plant lectin in vitro, and their tum...

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Detalles Bibliográficos
Autor principal: Walker, J. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009754/
https://www.ncbi.nlm.nih.gov/pubmed/728338
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author Walker, J. R.
author_facet Walker, J. R.
author_sort Walker, J. R.
collection PubMed
description A malignant cell line derived from the s.c. inoculation of Adenovirus 12 into a CBA mouse has been isolated in vitro, cloned, and within 10 passages the clones have been investigated for their karyotype, morphology, growth rate, saturation density and response to plant lectin in vitro, and their tumorigenicity and growth rate in vivo. The cell lines rapidly acquired a highly heterogeneous karyotype, but remained homogeneous with respect to more complex physiological parameters. Examination of the cellular characteristics has indicated that the rate of growth of the cell lines in vivo, but not their tumorigenicity, may be related to their in vitro potentials. The clones responded differently to the cytotoxic effects of concanavalin A, but there was no correlation between the effect of the lectin and the malignant potential of the cells. IMAGES:
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spelling pubmed-20097542009-09-10 Growth and transplantability of clonally related tumorigenic murine cell lines. Walker, J. R. Br J Cancer Research Article A malignant cell line derived from the s.c. inoculation of Adenovirus 12 into a CBA mouse has been isolated in vitro, cloned, and within 10 passages the clones have been investigated for their karyotype, morphology, growth rate, saturation density and response to plant lectin in vitro, and their tumorigenicity and growth rate in vivo. The cell lines rapidly acquired a highly heterogeneous karyotype, but remained homogeneous with respect to more complex physiological parameters. Examination of the cellular characteristics has indicated that the rate of growth of the cell lines in vivo, but not their tumorigenicity, may be related to their in vitro potentials. The clones responded differently to the cytotoxic effects of concanavalin A, but there was no correlation between the effect of the lectin and the malignant potential of the cells. IMAGES: Nature Publishing Group 1978-10 /pmc/articles/PMC2009754/ /pubmed/728338 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Walker, J. R.
Growth and transplantability of clonally related tumorigenic murine cell lines.
title Growth and transplantability of clonally related tumorigenic murine cell lines.
title_full Growth and transplantability of clonally related tumorigenic murine cell lines.
title_fullStr Growth and transplantability of clonally related tumorigenic murine cell lines.
title_full_unstemmed Growth and transplantability of clonally related tumorigenic murine cell lines.
title_short Growth and transplantability of clonally related tumorigenic murine cell lines.
title_sort growth and transplantability of clonally related tumorigenic murine cell lines.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009754/
https://www.ncbi.nlm.nih.gov/pubmed/728338
work_keys_str_mv AT walkerjr growthandtransplantabilityofclonallyrelatedtumorigenicmurinecelllines

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