NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours.

One hundred and nineteen specimens of human mammary tissue taken from 112 individuals, were inspected by pulsed proton magnetic-resonance techniques (at 22.5 MH2). The purpose of the study was to evaluate the diagnostic capabilities of the nuclear magnetic resonance (NMR) technique with regard to th...

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Detalles Bibliográficos
Autores principales: Goldsmith, M., Koutcher, J. A., Damadian, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009759/
https://www.ncbi.nlm.nih.gov/pubmed/728343
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author Goldsmith, M.
Koutcher, J. A.
Damadian, R.
author_facet Goldsmith, M.
Koutcher, J. A.
Damadian, R.
author_sort Goldsmith, M.
collection PubMed
description One hundred and nineteen specimens of human mammary tissue taken from 112 individuals, were inspected by pulsed proton magnetic-resonance techniques (at 22.5 MH2). The purpose of the study was to evaluate the diagnostic capabilities of the nuclear magnetic resonance (NMR) technique with regard to the recognition of malignancy. The combination of two NMR parameters (spin lattice (T1) and spin-spin(T2) relaxation times) into a malignancy index produced better than 95% discrimination between the 2 populations of tissue on a case-by-case basis. The mean and standard deviations obtained were 2.002 +/- 0.351 for normal tissue, and 3.137 +/- 0.667 for malignant specimens. The probability that this difference is not significant is considerably less than 0.01. In addition, specimens of fibrocystic disease and fibrous mastopathy had indices of 2.263 +/- 0.503 and 2.151 +/- 0.505 respectively. Both groups yielded P values less than 0.01 when compared to the malignant specimens.
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spelling pubmed-20097592009-09-10 NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours. Goldsmith, M. Koutcher, J. A. Damadian, R. Br J Cancer Research Article One hundred and nineteen specimens of human mammary tissue taken from 112 individuals, were inspected by pulsed proton magnetic-resonance techniques (at 22.5 MH2). The purpose of the study was to evaluate the diagnostic capabilities of the nuclear magnetic resonance (NMR) technique with regard to the recognition of malignancy. The combination of two NMR parameters (spin lattice (T1) and spin-spin(T2) relaxation times) into a malignancy index produced better than 95% discrimination between the 2 populations of tissue on a case-by-case basis. The mean and standard deviations obtained were 2.002 +/- 0.351 for normal tissue, and 3.137 +/- 0.667 for malignant specimens. The probability that this difference is not significant is considerably less than 0.01. In addition, specimens of fibrocystic disease and fibrous mastopathy had indices of 2.263 +/- 0.503 and 2.151 +/- 0.505 respectively. Both groups yielded P values less than 0.01 when compared to the malignant specimens. Nature Publishing Group 1978-10 /pmc/articles/PMC2009759/ /pubmed/728343 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Goldsmith, M.
Koutcher, J. A.
Damadian, R.
NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours.
title NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours.
title_full NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours.
title_fullStr NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours.
title_full_unstemmed NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours.
title_short NMR in cancer, XIII: application of the NMR malignancy index to human mammary tumours.
title_sort nmr in cancer, xiii: application of the nmr malignancy index to human mammary tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009759/
https://www.ncbi.nlm.nih.gov/pubmed/728343
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AT damadianr nmrincancerxiiiapplicationofthenmrmalignancyindextohumanmammarytumours

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