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Fatty metamorphosis and other patterns in fibrous dysplasia
BACKGROUND: Interpretation of small biopsy fragments from suspected lesions of fibrous dysplasia with unusual clinical and / or radiological features may be challenging due to wide histomorphological spectrum of stromal appearances. Awareness of these variations should improve diagnostic confidence....
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC200977/ https://www.ncbi.nlm.nih.gov/pubmed/12946277 http://dx.doi.org/10.1186/1471-2474-4-20 |
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author | Shidham, Vinod B Chavan, Ashwini Rao, R Nagarjun Komorowski, Richard A Asma, Zeenath |
author_facet | Shidham, Vinod B Chavan, Ashwini Rao, R Nagarjun Komorowski, Richard A Asma, Zeenath |
author_sort | Shidham, Vinod B |
collection | PubMed |
description | BACKGROUND: Interpretation of small biopsy fragments from suspected lesions of fibrous dysplasia with unusual clinical and / or radiological features may be challenging due to wide histomorphological spectrum of stromal appearances. Awareness of these variations should improve diagnostic confidence. METHODS: We retrospectively studied 26 cases of fibrous dysplasia (F- 19, M- 7; Ages ranged from 10 to 53 years) with confirmed diagnosis. The sites of the lesions were skull bones (9), humerus (1), femur (8), tibia (2), fibula (3), talus (1), mandible (1), and maxilla (1). RESULTS: Different stromal patterns, variably admixed with the classical pattern, were observed in 58%(15/26) of the cases. 20%(3/15) of these had more than one pattern. Focal fatty metamorphosis as groups of fat cells in the central portion of the lesion in the stroma of fibrous dysplasia between osseous trabeculae was observed in 23%(6/26) cases. Other patterns included myxoid stroma in 16%(4/26), collagenization of stroma in 12%(3/26), stroma rich pattern (with paucity of trabeculae) in 12%(3/26), foci of few foam cells in 23% (6/26), and calcified spherules in 12%(3/26). Focal osteoblastic rimming of trabeculae was observed only in 4%(1/26). CONCLUSIONS: Various stromal variations and previously unreported fatty metamorphosis were frequently observed in fibrous dysplasia. |
format | Text |
id | pubmed-200977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-2009772003-09-30 Fatty metamorphosis and other patterns in fibrous dysplasia Shidham, Vinod B Chavan, Ashwini Rao, R Nagarjun Komorowski, Richard A Asma, Zeenath BMC Musculoskelet Disord Research Article BACKGROUND: Interpretation of small biopsy fragments from suspected lesions of fibrous dysplasia with unusual clinical and / or radiological features may be challenging due to wide histomorphological spectrum of stromal appearances. Awareness of these variations should improve diagnostic confidence. METHODS: We retrospectively studied 26 cases of fibrous dysplasia (F- 19, M- 7; Ages ranged from 10 to 53 years) with confirmed diagnosis. The sites of the lesions were skull bones (9), humerus (1), femur (8), tibia (2), fibula (3), talus (1), mandible (1), and maxilla (1). RESULTS: Different stromal patterns, variably admixed with the classical pattern, were observed in 58%(15/26) of the cases. 20%(3/15) of these had more than one pattern. Focal fatty metamorphosis as groups of fat cells in the central portion of the lesion in the stroma of fibrous dysplasia between osseous trabeculae was observed in 23%(6/26) cases. Other patterns included myxoid stroma in 16%(4/26), collagenization of stroma in 12%(3/26), stroma rich pattern (with paucity of trabeculae) in 12%(3/26), foci of few foam cells in 23% (6/26), and calcified spherules in 12%(3/26). Focal osteoblastic rimming of trabeculae was observed only in 4%(1/26). CONCLUSIONS: Various stromal variations and previously unreported fatty metamorphosis were frequently observed in fibrous dysplasia. BioMed Central 2003-08-28 /pmc/articles/PMC200977/ /pubmed/12946277 http://dx.doi.org/10.1186/1471-2474-4-20 Text en Copyright © 2003 Shidham et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Research Article Shidham, Vinod B Chavan, Ashwini Rao, R Nagarjun Komorowski, Richard A Asma, Zeenath Fatty metamorphosis and other patterns in fibrous dysplasia |
title | Fatty metamorphosis and other patterns in fibrous dysplasia |
title_full | Fatty metamorphosis and other patterns in fibrous dysplasia |
title_fullStr | Fatty metamorphosis and other patterns in fibrous dysplasia |
title_full_unstemmed | Fatty metamorphosis and other patterns in fibrous dysplasia |
title_short | Fatty metamorphosis and other patterns in fibrous dysplasia |
title_sort | fatty metamorphosis and other patterns in fibrous dysplasia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC200977/ https://www.ncbi.nlm.nih.gov/pubmed/12946277 http://dx.doi.org/10.1186/1471-2474-4-20 |
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