Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.

C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose sho...

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Autores principales: Rostom, A. Y., Kauffman, S. L., Steel, G. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009771/
https://www.ncbi.nlm.nih.gov/pubmed/728340
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author Rostom, A. Y.
Kauffman, S. L.
Steel, G. G.
author_facet Rostom, A. Y.
Kauffman, S. L.
Steel, G. G.
author_sort Rostom, A. Y.
collection PubMed
description C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant. However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum. IMAGES:
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spelling pubmed-20097712009-09-10 Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice. Rostom, A. Y. Kauffman, S. L. Steel, G. G. Br J Cancer Research Article C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant. However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum. IMAGES: Nature Publishing Group 1978-10 /pmc/articles/PMC2009771/ /pubmed/728340 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Rostom, A. Y.
Kauffman, S. L.
Steel, G. G.
Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
title Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
title_full Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
title_fullStr Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
title_full_unstemmed Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
title_short Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
title_sort influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009771/
https://www.ncbi.nlm.nih.gov/pubmed/728340
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AT steelgg influenceofmisonidazoleontheincidenceofradiationinducedintestinaltumoursinmice

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