C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.

C-type viruses were formed in heterotransplants of 5/14 human urogenital tumours which had been serially transferred in nude mice of NIH(S) background. Except for one case in which C-type particles were present in the epithelial cells as well as the connective tissue, the viruses were only found wit...

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Autores principales: Wunderli, H., Mickey, D. D., Paulson, D. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009797/
https://www.ncbi.nlm.nih.gov/pubmed/215183
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author Wunderli, H.
Mickey, D. D.
Paulson, D. F.
author_facet Wunderli, H.
Mickey, D. D.
Paulson, D. F.
author_sort Wunderli, H.
collection PubMed
description C-type viruses were formed in heterotransplants of 5/14 human urogenital tumours which had been serially transferred in nude mice of NIH(S) background. Except for one case in which C-type particles were present in the epithelial cells as well as the connective tissue, the viruses were only found within the stroma of the heterotransplanted tumours. Peroxidase labelling with anti-mouse serum demonstrated that the connective tissue supporting the transplanted human tumours was of mouse origin. Competition radioimmunoassays demonstrated that MuLV interspecies viral protein was present in high titre in the transplanted tumour extracts and also in extracts of 2 spontaneous mouse-tumour extracts. These data suggest that endogenous viruses of the nude mice are activated by the graft, and only subsequently infect the human tumour cells and form particles. IMAGES:
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spelling pubmed-20097972009-09-10 C-type virus particles in human urogenital tumours after heterotransplantation into nude mice. Wunderli, H. Mickey, D. D. Paulson, D. F. Br J Cancer Research Article C-type viruses were formed in heterotransplants of 5/14 human urogenital tumours which had been serially transferred in nude mice of NIH(S) background. Except for one case in which C-type particles were present in the epithelial cells as well as the connective tissue, the viruses were only found within the stroma of the heterotransplanted tumours. Peroxidase labelling with anti-mouse serum demonstrated that the connective tissue supporting the transplanted human tumours was of mouse origin. Competition radioimmunoassays demonstrated that MuLV interspecies viral protein was present in high titre in the transplanted tumour extracts and also in extracts of 2 spontaneous mouse-tumour extracts. These data suggest that endogenous viruses of the nude mice are activated by the graft, and only subsequently infect the human tumour cells and form particles. IMAGES: Nature Publishing Group 1979-01 /pmc/articles/PMC2009797/ /pubmed/215183 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wunderli, H.
Mickey, D. D.
Paulson, D. F.
C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
title C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
title_full C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
title_fullStr C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
title_full_unstemmed C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
title_short C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
title_sort c-type virus particles in human urogenital tumours after heterotransplantation into nude mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009797/
https://www.ncbi.nlm.nih.gov/pubmed/215183
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AT mickeydd ctypevirusparticlesinhumanurogenitaltumoursafterheterotransplantationintonudemice
AT paulsondf ctypevirusparticlesinhumanurogenitaltumoursafterheterotransplantationintonudemice

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