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Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations.
Leucocyte-migration-inhibition test was used to study the immune reactions of leucocytes from 136 colorectal cancer patients, 43 patients with non-cancerous chronic colorectal diseases and 82 controls, with saline extracts of HT29 line. A positive inhibition was found in only 43% of colorectal cance...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1978
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009824/ https://www.ncbi.nlm.nih.gov/pubmed/743487 |
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author | Burtin, P. Pinset, C. Chany, E. Fondaneche, M. C. Chavanel, G. |
author_facet | Burtin, P. Pinset, C. Chany, E. Fondaneche, M. C. Chavanel, G. |
author_sort | Burtin, P. |
collection | PubMed |
description | Leucocyte-migration-inhibition test was used to study the immune reactions of leucocytes from 136 colorectal cancer patients, 43 patients with non-cancerous chronic colorectal diseases and 82 controls, with saline extracts of HT29 line. A positive inhibition was found in only 43% of colorectal cancer patients. It was higher in carcinomas of limited extension than in invasive ones (64% against 39%). Furthermore, operation by itself had a depressive effect on the reaction, as the positivity in 25 patients tested twice was 64% before operation and 32% after. Leucocytes from patients with non-cancerous chronic colorectal diseases gave many positive reactions (65%). The percentage of positivity was about the same for diseases with high, low or no risk of cancerization. Hence the antigen(s) of tumour extracts that react with patient's leucocytes are, at least partially, unrelated to cancer. |
format | Text |
id | pubmed-2009824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1978 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20098242009-09-10 Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. Burtin, P. Pinset, C. Chany, E. Fondaneche, M. C. Chavanel, G. Br J Cancer Research Article Leucocyte-migration-inhibition test was used to study the immune reactions of leucocytes from 136 colorectal cancer patients, 43 patients with non-cancerous chronic colorectal diseases and 82 controls, with saline extracts of HT29 line. A positive inhibition was found in only 43% of colorectal cancer patients. It was higher in carcinomas of limited extension than in invasive ones (64% against 39%). Furthermore, operation by itself had a depressive effect on the reaction, as the positivity in 25 patients tested twice was 64% before operation and 32% after. Leucocytes from patients with non-cancerous chronic colorectal diseases gave many positive reactions (65%). The percentage of positivity was about the same for diseases with high, low or no risk of cancerization. Hence the antigen(s) of tumour extracts that react with patient's leucocytes are, at least partially, unrelated to cancer. Nature Publishing Group 1978-12 /pmc/articles/PMC2009824/ /pubmed/743487 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Burtin, P. Pinset, C. Chany, E. Fondaneche, M. C. Chavanel, G. Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. |
title | Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. |
title_full | Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. |
title_fullStr | Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. |
title_full_unstemmed | Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. |
title_short | Leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. |
title_sort | leucocyte-migration-inhibition test in patients with colorectal cancer: clinicopathological correlations. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009824/ https://www.ncbi.nlm.nih.gov/pubmed/743487 |
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