Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.

Concentrations of misonidazole and its O-demethylated metabolite Ro 05-9963 in the plasma and saliva of 10 patients with malignant disease have been determined. A good linear correlation was established between plasma and saliva misonidazole concentration, and salivary sampling was found to be suita...

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Autores principales: Workman, P., Wiltshire, C. R., Plowman, P. N., Bleehen, N. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009825/
https://www.ncbi.nlm.nih.gov/pubmed/743488
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author Workman, P.
Wiltshire, C. R.
Plowman, P. N.
Bleehen, N. M.
author_facet Workman, P.
Wiltshire, C. R.
Plowman, P. N.
Bleehen, N. M.
author_sort Workman, P.
collection PubMed
description Concentrations of misonidazole and its O-demethylated metabolite Ro 05-9963 in the plasma and saliva of 10 patients with malignant disease have been determined. A good linear correlation was established between plasma and saliva misonidazole concentration, and salivary sampling was found to be suitable for the estimation of a number of pharmacokinetic parameters. Data are also presented for serial tumour cencentrations of misonidazole and Ro 05-9963 in 3 of the 10 patients. Monitoring of salivary misonidazole concentration appears to be a useful alternative to plasma monitoring, particularly for those patients in whom plasma sampling is unsuitable or impossible.
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spelling pubmed-20098252009-09-10 Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring. Workman, P. Wiltshire, C. R. Plowman, P. N. Bleehen, N. M. Br J Cancer Research Article Concentrations of misonidazole and its O-demethylated metabolite Ro 05-9963 in the plasma and saliva of 10 patients with malignant disease have been determined. A good linear correlation was established between plasma and saliva misonidazole concentration, and salivary sampling was found to be suitable for the estimation of a number of pharmacokinetic parameters. Data are also presented for serial tumour cencentrations of misonidazole and Ro 05-9963 in 3 of the 10 patients. Monitoring of salivary misonidazole concentration appears to be a useful alternative to plasma monitoring, particularly for those patients in whom plasma sampling is unsuitable or impossible. Nature Publishing Group 1978-12 /pmc/articles/PMC2009825/ /pubmed/743488 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Workman, P.
Wiltshire, C. R.
Plowman, P. N.
Bleehen, N. M.
Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
title Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
title_full Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
title_fullStr Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
title_full_unstemmed Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
title_short Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
title_sort monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009825/
https://www.ncbi.nlm.nih.gov/pubmed/743488
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AT bleehennm monitoringsalivarymisonidazoleinmanapossiblealternativetoplasmamonitoring

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