Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.

Concentrations of 5-fluorouracil (FU) were measured in the plasma of patients receiving i.v. infusions of the drug for 5 days as treatment for adenocarcinoma of the gastrointestinal tract. Concentrations of FU varied widely in many patients. Concentration of drug X time of infusion (C X t values) we...

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Autores principales: Hillcoat, B. L., McCulloch, P. B., Figueredo, A. T., Ehsan, M. H., Rosenfeld, J. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009832/
https://www.ncbi.nlm.nih.gov/pubmed/743489
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author Hillcoat, B. L.
McCulloch, P. B.
Figueredo, A. T.
Ehsan, M. H.
Rosenfeld, J. M.
author_facet Hillcoat, B. L.
McCulloch, P. B.
Figueredo, A. T.
Ehsan, M. H.
Rosenfeld, J. M.
author_sort Hillcoat, B. L.
collection PubMed
description Concentrations of 5-fluorouracil (FU) were measured in the plasma of patients receiving i.v. infusions of the drug for 5 days as treatment for adenocarcinoma of the gastrointestinal tract. Concentrations of FU varied widely in many patients. Concentration of drug X time of infusion (C X t values) were calculated. Patients showing a partial response or stabilization of disease had significantly higher C X t values than non-responders. Methyl CCNU did not affect the C X t values of FU. Determination of the plasma concentration of FU would allow the dose of the drug to be adjusted to maintain high concentrations of FU in the plasma. Our data suggest that such high concentrations would increase the response rate in this disease.
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spelling pubmed-20098322009-09-10 Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion. Hillcoat, B. L. McCulloch, P. B. Figueredo, A. T. Ehsan, M. H. Rosenfeld, J. M. Br J Cancer Research Article Concentrations of 5-fluorouracil (FU) were measured in the plasma of patients receiving i.v. infusions of the drug for 5 days as treatment for adenocarcinoma of the gastrointestinal tract. Concentrations of FU varied widely in many patients. Concentration of drug X time of infusion (C X t values) were calculated. Patients showing a partial response or stabilization of disease had significantly higher C X t values than non-responders. Methyl CCNU did not affect the C X t values of FU. Determination of the plasma concentration of FU would allow the dose of the drug to be adjusted to maintain high concentrations of FU in the plasma. Our data suggest that such high concentrations would increase the response rate in this disease. Nature Publishing Group 1978-12 /pmc/articles/PMC2009832/ /pubmed/743489 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hillcoat, B. L.
McCulloch, P. B.
Figueredo, A. T.
Ehsan, M. H.
Rosenfeld, J. M.
Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
title Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
title_full Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
title_fullStr Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
title_full_unstemmed Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
title_short Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
title_sort clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009832/
https://www.ncbi.nlm.nih.gov/pubmed/743489
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