Total urinary and free serum hydroxyproline in metastatic bone disease.

The present study examines the possibility of correlation between free serum and urinary total hydroxyproline and whether this correlation can be applied to clinical conditions. The correlation between the two indices was 0.80 (P less than 0.001) in 18 patients, mostly suffering from malignant disea...

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Autores principales: Gasser, A. B., Depierre, D., Courvoisier, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009870/
https://www.ncbi.nlm.nih.gov/pubmed/465297
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author Gasser, A. B.
Depierre, D.
Courvoisier, B.
author_facet Gasser, A. B.
Depierre, D.
Courvoisier, B.
author_sort Gasser, A. B.
collection PubMed
description The present study examines the possibility of correlation between free serum and urinary total hydroxyproline and whether this correlation can be applied to clinical conditions. The correlation between the two indices was 0.80 (P less than 0.001) in 18 patients, mostly suffering from malignant disease. On comparing the same measurements in 37 patients, all with known metastatic bone disease, we found 29/37 normal results for free serum hydroxyproline, whereas only 2/37 values of urinary total hydroxyproline were normal. The authors therefore conclude that urinary total hydroxyproline, measured as the ratio hydroxyproline/creatinine in a fresh specimen of early-morning urine, is the best index of collagen breakdown in metastatic bone disease and preferable to measurement of free serum hydroxyproline.
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spelling pubmed-20098702009-09-10 Total urinary and free serum hydroxyproline in metastatic bone disease. Gasser, A. B. Depierre, D. Courvoisier, B. Br J Cancer Research Article The present study examines the possibility of correlation between free serum and urinary total hydroxyproline and whether this correlation can be applied to clinical conditions. The correlation between the two indices was 0.80 (P less than 0.001) in 18 patients, mostly suffering from malignant disease. On comparing the same measurements in 37 patients, all with known metastatic bone disease, we found 29/37 normal results for free serum hydroxyproline, whereas only 2/37 values of urinary total hydroxyproline were normal. The authors therefore conclude that urinary total hydroxyproline, measured as the ratio hydroxyproline/creatinine in a fresh specimen of early-morning urine, is the best index of collagen breakdown in metastatic bone disease and preferable to measurement of free serum hydroxyproline. Nature Publishing Group 1979-03 /pmc/articles/PMC2009870/ /pubmed/465297 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gasser, A. B.
Depierre, D.
Courvoisier, B.
Total urinary and free serum hydroxyproline in metastatic bone disease.
title Total urinary and free serum hydroxyproline in metastatic bone disease.
title_full Total urinary and free serum hydroxyproline in metastatic bone disease.
title_fullStr Total urinary and free serum hydroxyproline in metastatic bone disease.
title_full_unstemmed Total urinary and free serum hydroxyproline in metastatic bone disease.
title_short Total urinary and free serum hydroxyproline in metastatic bone disease.
title_sort total urinary and free serum hydroxyproline in metastatic bone disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009870/
https://www.ncbi.nlm.nih.gov/pubmed/465297
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