Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.

A new series of LH-RH analogues containing an Azgly10 modification and having potent agonist properties were given in high concentration to intact female rats. Plasma LH and FSH were raised to extremely high levels after 14 days' administration of the compounds (5.0 and 0.5 microgram/rat twice...

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Autores principales: Maynard, P. V., Nicholson, R. I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009871/
https://www.ncbi.nlm.nih.gov/pubmed/380619
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author Maynard, P. V.
Nicholson, R. I.
author_facet Maynard, P. V.
Nicholson, R. I.
author_sort Maynard, P. V.
collection PubMed
description A new series of LH-RH analogues containing an Azgly10 modification and having potent agonist properties were given in high concentration to intact female rats. Plasma LH and FSH were raised to extremely high levels after 14 days' administration of the compounds (5.0 and 0.5 microgram/rat twice daily), but plasma oestradiol concentrations were reduced to those in ovariectomized rats. The weights of the ovary and uterus were also markedly reduced, suggesting that these compounds are, on this treatment regime, producing the effects of chemical castration.
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spelling pubmed-20098712009-09-10 Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats. Maynard, P. V. Nicholson, R. I. Br J Cancer Research Article A new series of LH-RH analogues containing an Azgly10 modification and having potent agonist properties were given in high concentration to intact female rats. Plasma LH and FSH were raised to extremely high levels after 14 days' administration of the compounds (5.0 and 0.5 microgram/rat twice daily), but plasma oestradiol concentrations were reduced to those in ovariectomized rats. The weights of the ovary and uterus were also markedly reduced, suggesting that these compounds are, on this treatment regime, producing the effects of chemical castration. Nature Publishing Group 1979-03 /pmc/articles/PMC2009871/ /pubmed/380619 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Maynard, P. V.
Nicholson, R. I.
Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.
title Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.
title_full Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.
title_fullStr Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.
title_full_unstemmed Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.
title_short Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.
title_sort effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009871/
https://www.ncbi.nlm.nih.gov/pubmed/380619
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