Relationship of natural killer-cell activity to rhesus antigens in man.

A number of previous studies have shown that the level of natural killer (NK) cell activity in humans is relatively constant for a given individual but varies widely between individuals. The factors which determine this variability are largely unknown, but genetic factors appear to be involved. In t...

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Detalles Bibliográficos
Autores principales: Hersey, P., Edwards, A., Trilivas, C., Shaw, H., Milton, G. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009882/
https://www.ncbi.nlm.nih.gov/pubmed/111695
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author Hersey, P.
Edwards, A.
Trilivas, C.
Shaw, H.
Milton, G. W.
author_facet Hersey, P.
Edwards, A.
Trilivas, C.
Shaw, H.
Milton, G. W.
author_sort Hersey, P.
collection PubMed
description A number of previous studies have shown that the level of natural killer (NK) cell activity in humans is relatively constant for a given individual but varies widely between individuals. The factors which determine this variability are largely unknown, but genetic factors appear to be involved. In the present study it was found that Rh- normal subjects and melanoma patients had significantly higher natural cytotoxicity to target cells than Rh+ patients. This difference did not appear to be due to sensitization against Rh antigens on the target cell and may indicate that genes determining NK-cell activity are associated with those determining the expression of Rh antigens. Analysis of the survival data for Rh- and Rh+ patients did not reveal any increase in survival attributable to the higher natural cytotoxicity in Rh- patients.
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spelling pubmed-20098822009-09-10 Relationship of natural killer-cell activity to rhesus antigens in man. Hersey, P. Edwards, A. Trilivas, C. Shaw, H. Milton, G. W. Br J Cancer Research Article A number of previous studies have shown that the level of natural killer (NK) cell activity in humans is relatively constant for a given individual but varies widely between individuals. The factors which determine this variability are largely unknown, but genetic factors appear to be involved. In the present study it was found that Rh- normal subjects and melanoma patients had significantly higher natural cytotoxicity to target cells than Rh+ patients. This difference did not appear to be due to sensitization against Rh antigens on the target cell and may indicate that genes determining NK-cell activity are associated with those determining the expression of Rh antigens. Analysis of the survival data for Rh- and Rh+ patients did not reveal any increase in survival attributable to the higher natural cytotoxicity in Rh- patients. Nature Publishing Group 1979-03 /pmc/articles/PMC2009882/ /pubmed/111695 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hersey, P.
Edwards, A.
Trilivas, C.
Shaw, H.
Milton, G. W.
Relationship of natural killer-cell activity to rhesus antigens in man.
title Relationship of natural killer-cell activity to rhesus antigens in man.
title_full Relationship of natural killer-cell activity to rhesus antigens in man.
title_fullStr Relationship of natural killer-cell activity to rhesus antigens in man.
title_full_unstemmed Relationship of natural killer-cell activity to rhesus antigens in man.
title_short Relationship of natural killer-cell activity to rhesus antigens in man.
title_sort relationship of natural killer-cell activity to rhesus antigens in man.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009882/
https://www.ncbi.nlm.nih.gov/pubmed/111695
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