Elastosis and response to endocrine therapy in human breast cancer.

Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than t...

Descripción completa

Detalles Bibliográficos
Autores principales: Masters, J. R., Millis, R. R., King, R. J., Rubens, R. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009905/
https://www.ncbi.nlm.nih.gov/pubmed/486310
_version_ 1782136210156683264
author Masters, J. R.
Millis, R. R.
King, R. J.
Rubens, R. D.
author_facet Masters, J. R.
Millis, R. R.
King, R. J.
Rubens, R. D.
author_sort Masters, J. R.
collection PubMed
description Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross elastosis, indicating that this simple method might provide a useful predictive index for response to endocrine therapy. In addition, tumours with oestrogen-receptor activity (a feature associated with a high rate of response) but with no elastosis were unlikely to respond, suggesting that a combination of the 2 predictive indices might be more valuable than either taken alone.
format Text
id pubmed-2009905
institution National Center for Biotechnology Information
language English
publishDate 1979
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20099052009-09-10 Elastosis and response to endocrine therapy in human breast cancer. Masters, J. R. Millis, R. R. King, R. J. Rubens, R. D. Br J Cancer Research Article Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross elastosis, indicating that this simple method might provide a useful predictive index for response to endocrine therapy. In addition, tumours with oestrogen-receptor activity (a feature associated with a high rate of response) but with no elastosis were unlikely to respond, suggesting that a combination of the 2 predictive indices might be more valuable than either taken alone. Nature Publishing Group 1979-05 /pmc/articles/PMC2009905/ /pubmed/486310 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Masters, J. R.
Millis, R. R.
King, R. J.
Rubens, R. D.
Elastosis and response to endocrine therapy in human breast cancer.
title Elastosis and response to endocrine therapy in human breast cancer.
title_full Elastosis and response to endocrine therapy in human breast cancer.
title_fullStr Elastosis and response to endocrine therapy in human breast cancer.
title_full_unstemmed Elastosis and response to endocrine therapy in human breast cancer.
title_short Elastosis and response to endocrine therapy in human breast cancer.
title_sort elastosis and response to endocrine therapy in human breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009905/
https://www.ncbi.nlm.nih.gov/pubmed/486310
work_keys_str_mv AT mastersjr elastosisandresponsetoendocrinetherapyinhumanbreastcancer
AT millisrr elastosisandresponsetoendocrinetherapyinhumanbreastcancer
AT kingrj elastosisandresponsetoendocrinetherapyinhumanbreastcancer
AT rubensrd elastosisandresponsetoendocrinetherapyinhumanbreastcancer

Ejemplares similares