Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.

Antioxidants were found to inhibit the mixed-function oxidation of benzo(a)pyrene in several tissues of untreated and 3-methylcholanthrene-pretreated rats. The enzyme systems in the liver, kidney and stomach were much more susceptible to inhibition than those in the lung, adrenal, colon and small in...

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Detalles Bibliográficos
Autores principales: Rahimtula, A. D., Zachariah, P. K., O'Brien, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009946/
https://www.ncbi.nlm.nih.gov/pubmed/454558
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author Rahimtula, A. D.
Zachariah, P. K.
O'Brien, P. J.
author_facet Rahimtula, A. D.
Zachariah, P. K.
O'Brien, P. J.
author_sort Rahimtula, A. D.
collection PubMed
description Antioxidants were found to inhibit the mixed-function oxidation of benzo(a)pyrene in several tissues of untreated and 3-methylcholanthrene-pretreated rats. The enzyme systems in the liver, kidney and stomach were much more susceptible to inhibition than those in the lung, adrenal, colon and small intestine. In all tissues except the stomach it was found that 3-methylcholanthrene pretreatment led to a decrease in inhibition of benzo(a)pyrene 3-hydroxylase activity. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites. Of the various steroids tested, only 17 beta-oestradiol and oestrone were significantly inhibitory in most tissues. Cholesterol was found to increase benzo(a)pyrene 3-hydroxylase activity in the gastrointestinal tract.
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spelling pubmed-20099462009-09-10 Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat. Rahimtula, A. D. Zachariah, P. K. O'Brien, P. J. Br J Cancer Research Article Antioxidants were found to inhibit the mixed-function oxidation of benzo(a)pyrene in several tissues of untreated and 3-methylcholanthrene-pretreated rats. The enzyme systems in the liver, kidney and stomach were much more susceptible to inhibition than those in the lung, adrenal, colon and small intestine. In all tissues except the stomach it was found that 3-methylcholanthrene pretreatment led to a decrease in inhibition of benzo(a)pyrene 3-hydroxylase activity. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites. Of the various steroids tested, only 17 beta-oestradiol and oestrone were significantly inhibitory in most tissues. Cholesterol was found to increase benzo(a)pyrene 3-hydroxylase activity in the gastrointestinal tract. Nature Publishing Group 1979-07 /pmc/articles/PMC2009946/ /pubmed/454558 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Rahimtula, A. D.
Zachariah, P. K.
O'Brien, P. J.
Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
title Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
title_full Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
title_fullStr Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
title_full_unstemmed Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
title_short Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
title_sort differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009946/
https://www.ncbi.nlm.nih.gov/pubmed/454558
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