An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.

Anti-NSA3 antiserum was found to react with many kinds of benign and malignant tumours, as well as foetal skin and intestinal extracts. The corresponding antigens isolated from nervous tissue, benign breast adenoma, and a fibrosarcoma were compared. Immunoprecipitation cannot distinguish between the...

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Autores principales: Delpech, B., Delpech, A., Girard, N., Chauzy, C., Laumonier, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009949/
https://www.ncbi.nlm.nih.gov/pubmed/89856
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author Delpech, B.
Delpech, A.
Girard, N.
Chauzy, C.
Laumonier, R.
author_facet Delpech, B.
Delpech, A.
Girard, N.
Chauzy, C.
Laumonier, R.
author_sort Delpech, B.
collection PubMed
description Anti-NSA3 antiserum was found to react with many kinds of benign and malignant tumours, as well as foetal skin and intestinal extracts. The corresponding antigens isolated from nervous tissue, benign breast adenoma, and a fibrosarcoma were compared. Immunoprecipitation cannot distinguish between these antigens, and their amino-acid contents were comparable. However, immuno-absorption identified an antigenic determinant that was confined to nervous tissue. Indirect immunofluorescence further confirmed the validity of the concept of a nervous form vs a mesenchymal form of the antigen. Furthermore, immunofluorescence enabled the localization of the antigen found in non-nervous tissue to mesenchyme (mesenchyme-associated antigen: MAA), whether the mesenchymal tissue be normal (foetal organs), tumoral (fibrosarcoma) or reactional (connective-tissue stroma of epithelial tumours). IMAGES:
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spelling pubmed-20099492009-09-10 An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein. Delpech, B. Delpech, A. Girard, N. Chauzy, C. Laumonier, R. Br J Cancer Research Article Anti-NSA3 antiserum was found to react with many kinds of benign and malignant tumours, as well as foetal skin and intestinal extracts. The corresponding antigens isolated from nervous tissue, benign breast adenoma, and a fibrosarcoma were compared. Immunoprecipitation cannot distinguish between these antigens, and their amino-acid contents were comparable. However, immuno-absorption identified an antigenic determinant that was confined to nervous tissue. Indirect immunofluorescence further confirmed the validity of the concept of a nervous form vs a mesenchymal form of the antigen. Furthermore, immunofluorescence enabled the localization of the antigen found in non-nervous tissue to mesenchyme (mesenchyme-associated antigen: MAA), whether the mesenchymal tissue be normal (foetal organs), tumoral (fibrosarcoma) or reactional (connective-tissue stroma of epithelial tumours). IMAGES: Nature Publishing Group 1979-07 /pmc/articles/PMC2009949/ /pubmed/89856 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Delpech, B.
Delpech, A.
Girard, N.
Chauzy, C.
Laumonier, R.
An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.
title An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.
title_full An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.
title_fullStr An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.
title_full_unstemmed An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.
title_short An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.
title_sort antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009949/
https://www.ncbi.nlm.nih.gov/pubmed/89856
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