Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.

The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholest...

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Autores principales: Richardson, V. J., Ryman, B. E., Jewkes, R. F., Jeyasingh, K., Tattersall, M. N., Newlands, E. S., Kaye, S. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009957/
https://www.ncbi.nlm.nih.gov/pubmed/475960
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author Richardson, V. J.
Ryman, B. E.
Jewkes, R. F.
Jeyasingh, K.
Tattersall, M. N.
Newlands, E. S.
Kaye, S. B.
author_facet Richardson, V. J.
Ryman, B. E.
Jewkes, R. F.
Jeyasingh, K.
Tattersall, M. N.
Newlands, E. S.
Kaye, S. B.
author_sort Richardson, V. J.
collection PubMed
description The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic acid) were used in a study of 13 patients with advanced cancer and one with polycythaemia rubra vera (PRV). In all cases except the patient with PRV the major site of uptake of the label was the liver and spleen. In the patient with PRV the liver uptake was greatly reduced and the major site of uptake was found in regions corresponding to marrow. With the exception of one patient with a primary hepatoma, there was no significant tumour uptake of the label. IMAGES:
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spelling pubmed-20099572009-09-10 Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients. Richardson, V. J. Ryman, B. E. Jewkes, R. F. Jeyasingh, K. Tattersall, M. N. Newlands, E. S. Kaye, S. B. Br J Cancer Research Article The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic acid) were used in a study of 13 patients with advanced cancer and one with polycythaemia rubra vera (PRV). In all cases except the patient with PRV the major site of uptake of the label was the liver and spleen. In the patient with PRV the liver uptake was greatly reduced and the major site of uptake was found in regions corresponding to marrow. With the exception of one patient with a primary hepatoma, there was no significant tumour uptake of the label. IMAGES: Nature Publishing Group 1979-07 /pmc/articles/PMC2009957/ /pubmed/475960 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Richardson, V. J.
Ryman, B. E.
Jewkes, R. F.
Jeyasingh, K.
Tattersall, M. N.
Newlands, E. S.
Kaye, S. B.
Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
title Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
title_full Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
title_fullStr Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
title_full_unstemmed Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
title_short Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
title_sort tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009957/
https://www.ncbi.nlm.nih.gov/pubmed/475960
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