Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.

A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-F...

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Autores principales: Higgins, P. J., Tong, C., Borenfreund, E., Okin, R. S., Bendich, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010012/
https://www.ncbi.nlm.nih.gov/pubmed/475970
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author Higgins, P. J.
Tong, C.
Borenfreund, E.
Okin, R. S.
Bendich, A.
author_facet Higgins, P. J.
Tong, C.
Borenfreund, E.
Okin, R. S.
Bendich, A.
author_sort Higgins, P. J.
collection PubMed
description A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus and tumour was obtained by molecular-sieve chromatography and sucrose-gradient centrifugation. Radial immunodiffusion analyses of organ extracts indicated that gamma-FA could be found in several neonatal tissues, the highest concentration occurring in the spleen. In the 2-month-old mouse, only splenic tissue contained gamma-FA and at much lower levels than in the organ of the newborn mouse. IMAGES:
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spelling pubmed-20100122009-09-10 Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen. Higgins, P. J. Tong, C. Borenfreund, E. Okin, R. S. Bendich, A. Br J Cancer Research Article A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus and tumour was obtained by molecular-sieve chromatography and sucrose-gradient centrifugation. Radial immunodiffusion analyses of organ extracts indicated that gamma-FA could be found in several neonatal tissues, the highest concentration occurring in the spleen. In the 2-month-old mouse, only splenic tissue contained gamma-FA and at much lower levels than in the organ of the newborn mouse. IMAGES: Nature Publishing Group 1979-08 /pmc/articles/PMC2010012/ /pubmed/475970 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Higgins, P. J.
Tong, C.
Borenfreund, E.
Okin, R. S.
Bendich, A.
Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
title Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
title_full Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
title_fullStr Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
title_full_unstemmed Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
title_short Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
title_sort tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010012/
https://www.ncbi.nlm.nih.gov/pubmed/475970
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