Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.

The transplantable Guerin epithelioma in Wistar rats was used to test the in vivo effectiveness of 1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole (P1) as a tumour-cell radiosensitizer after its oral administration at relatively low doses. The radiosensitizing ability of P1 was compared with...

Descripción completa

Detalles Bibliográficos
Autores principales: Watras, J., Wideł, M., Suwiński, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010047/
https://www.ncbi.nlm.nih.gov/pubmed/508563
_version_ 1782136239128838144
author Watras, J.
Wideł, M.
Suwiński, J.
author_facet Watras, J.
Wideł, M.
Suwiński, J.
author_sort Watras, J.
collection PubMed
description The transplantable Guerin epithelioma in Wistar rats was used to test the in vivo effectiveness of 1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole (P1) as a tumour-cell radiosensitizer after its oral administration at relatively low doses. The radiosensitizing ability of P1 was compared with that of metronidazole. The results indicate that P1 is less toxic than metronidazole, and greater concentrations of P1 in blood and tumour tissues are obtained for the same administered dose of the compounds. The radiosensitizing ability of P1, determined from tumour-regression rates and local-control percentage at 130 days, was higher than that of metronidazole.
format Text
id pubmed-2010047
institution National Center for Biotechnology Information
language English
publishDate 1979
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20100472009-09-10 Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole. Watras, J. Wideł, M. Suwiński, J. Br J Cancer Research Article The transplantable Guerin epithelioma in Wistar rats was used to test the in vivo effectiveness of 1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole (P1) as a tumour-cell radiosensitizer after its oral administration at relatively low doses. The radiosensitizing ability of P1 was compared with that of metronidazole. The results indicate that P1 is less toxic than metronidazole, and greater concentrations of P1 in blood and tumour tissues are obtained for the same administered dose of the compounds. The radiosensitizing ability of P1, determined from tumour-regression rates and local-control percentage at 130 days, was higher than that of metronidazole. Nature Publishing Group 1979-09 /pmc/articles/PMC2010047/ /pubmed/508563 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Watras, J.
Wideł, M.
Suwiński, J.
Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
title Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
title_full Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
title_fullStr Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
title_full_unstemmed Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
title_short Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
title_sort response of the solid guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010047/
https://www.ncbi.nlm.nih.gov/pubmed/508563
work_keys_str_mv AT watrasj responseofthesolidguerinepitheliomasofratstofractionatedirradiationandanew4nitroimidazole
AT widełm responseofthesolidguerinepitheliomasofratstofractionatedirradiationandanew4nitroimidazole
AT suwinskij responseofthesolidguerinepitheliomasofratstofractionatedirradiationandanew4nitroimidazole

Ejemplares similares