Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.

The chronic administration of N-2-acetylaminofluorene (N-2-AAF) to rats causes a loss of hepatic cytoplasmic RNA, particularly from the endoplasmic-membrane fractions. At the end of the complete carcinogenic dose, the level of amino-acid incorporation into proalbumin is normal, despite the loss of 3...

Descripción completa

Detalles Bibliográficos
Autores principales: Harson, M. M., Williams, D. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010110/
https://www.ncbi.nlm.nih.gov/pubmed/508581
_version_ 1782136252267495424
author Harson, M. M.
Williams, D. J.
author_facet Harson, M. M.
Williams, D. J.
author_sort Harson, M. M.
collection PubMed
description The chronic administration of N-2-acetylaminofluorene (N-2-AAF) to rats causes a loss of hepatic cytoplasmic RNA, particularly from the endoplasmic-membrane fractions. At the end of the complete carcinogenic dose, the level of amino-acid incorporation into proalbumin is normal, despite the loss of 35% of membrane-bound RNA. The secretion of albumin, however, is inhibited. This inhibition of secretion is apparently the result of a change in membrane flow and differentiation; transfer of nascent protein from smooth-surfaced vesicles to the Golgi apparatus is blocked. The significance of these findings is discussed.
format Text
id pubmed-2010110
institution National Center for Biotechnology Information
language English
publishDate 1979
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20101102009-09-10 Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene. Harson, M. M. Williams, D. J. Br J Cancer Research Article The chronic administration of N-2-acetylaminofluorene (N-2-AAF) to rats causes a loss of hepatic cytoplasmic RNA, particularly from the endoplasmic-membrane fractions. At the end of the complete carcinogenic dose, the level of amino-acid incorporation into proalbumin is normal, despite the loss of 35% of membrane-bound RNA. The secretion of albumin, however, is inhibited. This inhibition of secretion is apparently the result of a change in membrane flow and differentiation; transfer of nascent protein from smooth-surfaced vesicles to the Golgi apparatus is blocked. The significance of these findings is discussed. Nature Publishing Group 1979-11 /pmc/articles/PMC2010110/ /pubmed/508581 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Harson, M. M.
Williams, D. J.
Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.
title Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.
title_full Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.
title_fullStr Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.
title_full_unstemmed Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.
title_short Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.
title_sort synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of n-2-acetylaminofluorene.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010110/
https://www.ncbi.nlm.nih.gov/pubmed/508581
work_keys_str_mv AT harsonmm synthesisandsecretionofalbumininratsduringtreatmentwithacarcinogenicdoseofn2acetylaminofluorene
AT williamsdj synthesisandsecretionofalbumininratsduringtreatmentwithacarcinogenicdoseofn2acetylaminofluorene

Ejemplares similares