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Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was indepe...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
1979
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010144/ https://www.ncbi.nlm.nih.gov/pubmed/294292 |
| Sumario: | A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described. IMAGES: |
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