Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.

A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was indepe...

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Autor principal: Major, I. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010144/
https://www.ncbi.nlm.nih.gov/pubmed/294292
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author Major, I. R.
author_facet Major, I. R.
author_sort Major, I. R.
collection PubMed
description A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described. IMAGES:
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spelling pubmed-20101442009-09-10 Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays. Major, I. R. Br J Cancer Research Article A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described. IMAGES: Nature Publishing Group 1979-12 /pmc/articles/PMC2010144/ /pubmed/294292 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Major, I. R.
Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
title Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
title_full Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
title_fullStr Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
title_full_unstemmed Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
title_short Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
title_sort induction of myeloid leukaemia by whole-body single exposure of cba male mice to x-rays.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010144/
https://www.ncbi.nlm.nih.gov/pubmed/294292
work_keys_str_mv AT majorir inductionofmyeloidleukaemiabywholebodysingleexposureofcbamalemicetoxrays

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