Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.

Mononuclear leucocytes were separated by Hypaque--Ficoll from 60 unselected primary colorectal carcinomas, and then fractionated by rosetting with sheep erythrocytes, either alone (E) or coated with antibody and complement (EAC). The E-rosetting cells, putative T lymphocytes, were cytotoxic in vitro...

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Autores principales: Werkmeister, J. A., Pihl, E., Nind, A. P., Flannery, G. R., Nairn, R. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010150/
https://www.ncbi.nlm.nih.gov/pubmed/316708
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author Werkmeister, J. A.
Pihl, E.
Nind, A. P.
Flannery, G. R.
Nairn, R. C.
author_facet Werkmeister, J. A.
Pihl, E.
Nind, A. P.
Flannery, G. R.
Nairn, R. C.
author_sort Werkmeister, J. A.
collection PubMed
description Mononuclear leucocytes were separated by Hypaque--Ficoll from 60 unselected primary colorectal carcinomas, and then fractionated by rosetting with sheep erythrocytes, either alone (E) or coated with antibody and complement (EAC). The E-rosetting cells, putative T lymphocytes, were cytotoxic in vitro to autologous tumour cells in 18 of the 60 cases, whilst the EAC-rosetting cells were unreactive. This intrinsic T-lymphocyte anti-tumour immunoreactivity was significantly associated with the presence of "cuffs" of small dark lymphocytes at the mesocolic or pararectal edge of the primary tumours, but there was no correlation with antitumour cytotoxic lymphocytes in the patient's blood at the time of operation. IMAGES:
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spelling pubmed-20101502009-09-10 Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma. Werkmeister, J. A. Pihl, E. Nind, A. P. Flannery, G. R. Nairn, R. C. Br J Cancer Research Article Mononuclear leucocytes were separated by Hypaque--Ficoll from 60 unselected primary colorectal carcinomas, and then fractionated by rosetting with sheep erythrocytes, either alone (E) or coated with antibody and complement (EAC). The E-rosetting cells, putative T lymphocytes, were cytotoxic in vitro to autologous tumour cells in 18 of the 60 cases, whilst the EAC-rosetting cells were unreactive. This intrinsic T-lymphocyte anti-tumour immunoreactivity was significantly associated with the presence of "cuffs" of small dark lymphocytes at the mesocolic or pararectal edge of the primary tumours, but there was no correlation with antitumour cytotoxic lymphocytes in the patient's blood at the time of operation. IMAGES: Nature Publishing Group 1979-12 /pmc/articles/PMC2010150/ /pubmed/316708 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Werkmeister, J. A.
Pihl, E.
Nind, A. P.
Flannery, G. R.
Nairn, R. C.
Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.
title Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.
title_full Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.
title_fullStr Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.
title_full_unstemmed Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.
title_short Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.
title_sort immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010150/
https://www.ncbi.nlm.nih.gov/pubmed/316708
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AT nindap immunoreactivitybyintrinsiclymphoidcellsincolorectalcarcinoma
AT flannerygr immunoreactivitybyintrinsiclymphoidcellsincolorectalcarcinoma
AT nairnrc immunoreactivitybyintrinsiclymphoidcellsincolorectalcarcinoma

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