Mechanisms of C. Parvum-induced coagulopathy in mice.

I.v. injection of Corynebacterium parvum (CP) into C57BL and BALB/c mice caused profound coagulation changes, featuring thrombocytopenia, decreased fibrinogen, increased fibrin/fibrinogen degradation products, and a concomitant microangiopathic haemolytic anaemia. These changes were greatest on the...

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Autores principales: Mitcheson, H. D., Hilgard, P., McCraw, A., Castro, J. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010159/
https://www.ncbi.nlm.nih.gov/pubmed/7362773
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author Mitcheson, H. D.
Hilgard, P.
McCraw, A.
Castro, J. E.
author_facet Mitcheson, H. D.
Hilgard, P.
McCraw, A.
Castro, J. E.
author_sort Mitcheson, H. D.
collection PubMed
description I.v. injection of Corynebacterium parvum (CP) into C57BL and BALB/c mice caused profound coagulation changes, featuring thrombocytopenia, decreased fibrinogen, increased fibrin/fibrinogen degradation products, and a concomitant microangiopathic haemolytic anaemia. These changes were greatest on the 9th day after CP, with recovery by Day 21. I.p. injection caused similar effects but s.c. injection was ineffective. Radiolabelled-platelet kinetics and distribution after i.v. CP indicated disseminated intravascular coagulation with rapid fibrinolysis; EACA treatment exacerbated the thrombosis. The coagulopathy correlated with hepatosplenomegaly, and both were dose dependent. Splenectomy did not effect the coagulopathy, but indomethacin totally abrogated the changes, suggesting that prostaglandin biosynthesis is involved in the pathogenesis.
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spelling pubmed-20101592009-09-10 Mechanisms of C. Parvum-induced coagulopathy in mice. Mitcheson, H. D. Hilgard, P. McCraw, A. Castro, J. E. Br J Cancer Research Article I.v. injection of Corynebacterium parvum (CP) into C57BL and BALB/c mice caused profound coagulation changes, featuring thrombocytopenia, decreased fibrinogen, increased fibrin/fibrinogen degradation products, and a concomitant microangiopathic haemolytic anaemia. These changes were greatest on the 9th day after CP, with recovery by Day 21. I.p. injection caused similar effects but s.c. injection was ineffective. Radiolabelled-platelet kinetics and distribution after i.v. CP indicated disseminated intravascular coagulation with rapid fibrinolysis; EACA treatment exacerbated the thrombosis. The coagulopathy correlated with hepatosplenomegaly, and both were dose dependent. Splenectomy did not effect the coagulopathy, but indomethacin totally abrogated the changes, suggesting that prostaglandin biosynthesis is involved in the pathogenesis. Nature Publishing Group 1980-01 /pmc/articles/PMC2010159/ /pubmed/7362773 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Mitcheson, H. D.
Hilgard, P.
McCraw, A.
Castro, J. E.
Mechanisms of C. Parvum-induced coagulopathy in mice.
title Mechanisms of C. Parvum-induced coagulopathy in mice.
title_full Mechanisms of C. Parvum-induced coagulopathy in mice.
title_fullStr Mechanisms of C. Parvum-induced coagulopathy in mice.
title_full_unstemmed Mechanisms of C. Parvum-induced coagulopathy in mice.
title_short Mechanisms of C. Parvum-induced coagulopathy in mice.
title_sort mechanisms of c. parvum-induced coagulopathy in mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010159/
https://www.ncbi.nlm.nih.gov/pubmed/7362773
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