Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.

Chinese hamster, HeLa and HAK cells were treated with methotrexate (MTX) to determine the dependence of its effect on drug concentration and exposure time. With a broad range of survival curves for Chinese hamster cells, cell survival is an exponential function of exposure time and a power function...

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Detalles Bibliográficos
Autores principales: Eichholtz, H., Trott, K. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010205/
https://www.ncbi.nlm.nih.gov/pubmed/7370167
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author Eichholtz, H.
Trott, K. R.
author_facet Eichholtz, H.
Trott, K. R.
author_sort Eichholtz, H.
collection PubMed
description Chinese hamster, HeLa and HAK cells were treated with methotrexate (MTX) to determine the dependence of its effect on drug concentration and exposure time. With a broad range of survival curves for Chinese hamster cells, cell survival is an exponential function of exposure time and a power function of drug concentration. The data allow a mathematical description to be made of the interdependence of MTX concentration and drug exposure in relation to cell survival.
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spelling pubmed-20102052009-09-10 Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro. Eichholtz, H. Trott, K. R. Br J Cancer Research Article Chinese hamster, HeLa and HAK cells were treated with methotrexate (MTX) to determine the dependence of its effect on drug concentration and exposure time. With a broad range of survival curves for Chinese hamster cells, cell survival is an exponential function of exposure time and a power function of drug concentration. The data allow a mathematical description to be made of the interdependence of MTX concentration and drug exposure in relation to cell survival. Nature Publishing Group 1980-02 /pmc/articles/PMC2010205/ /pubmed/7370167 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Eichholtz, H.
Trott, K. R.
Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
title Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
title_full Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
title_fullStr Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
title_full_unstemmed Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
title_short Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
title_sort effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010205/
https://www.ncbi.nlm.nih.gov/pubmed/7370167
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