An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.

Intra-oral squamous-cell carcinomas occurred in over 50% of the HMT inbred strain of rats. In the outbred stock from which it was derived the incidence was 5% or less, both when inbreeding was begun and after the inbred strain was fully established. Various factors in food and husbandry which might...

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Autores principales: Buckley, P., Hulse, E. V., Keep, B. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010213/
https://www.ncbi.nlm.nih.gov/pubmed/7370169
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author Buckley, P.
Hulse, E. V.
Keep, B. M.
author_facet Buckley, P.
Hulse, E. V.
Keep, B. M.
author_sort Buckley, P.
collection PubMed
description Intra-oral squamous-cell carcinomas occurred in over 50% of the HMT inbred strain of rats. In the outbred stock from which it was derived the incidence was 5% or less, both when inbreeding was begun and after the inbred strain was fully established. Various factors in food and husbandry which might have irritated the oral mucosa were investigated, but there was no signficiant evidence that they played any part in the high incidence of mouth tumours. It is concluded that there must have been an accidental selection during inbreeding in favour of rats which had an inherited tendency to develop squamous-cell carcinoma of the mouth. There are a number of similarities between the rat tumour and intra-oral squamous-cell carcinoma in man and it is suggested that the rat tumour could be used as a model of the human disease. IMAGES:
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spelling pubmed-20102132009-09-10 An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth. Buckley, P. Hulse, E. V. Keep, B. M. Br J Cancer Research Article Intra-oral squamous-cell carcinomas occurred in over 50% of the HMT inbred strain of rats. In the outbred stock from which it was derived the incidence was 5% or less, both when inbreeding was begun and after the inbred strain was fully established. Various factors in food and husbandry which might have irritated the oral mucosa were investigated, but there was no signficiant evidence that they played any part in the high incidence of mouth tumours. It is concluded that there must have been an accidental selection during inbreeding in favour of rats which had an inherited tendency to develop squamous-cell carcinoma of the mouth. There are a number of similarities between the rat tumour and intra-oral squamous-cell carcinoma in man and it is suggested that the rat tumour could be used as a model of the human disease. IMAGES: Nature Publishing Group 1980-02 /pmc/articles/PMC2010213/ /pubmed/7370169 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Buckley, P.
Hulse, E. V.
Keep, B. M.
An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.
title An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.
title_full An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.
title_fullStr An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.
title_full_unstemmed An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.
title_short An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.
title_sort inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010213/
https://www.ncbi.nlm.nih.gov/pubmed/7370169
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