Clearance of immune complexes formed in normal and leukaemic rats.

Immune complexes of 125I-HSA-rat anti-HSA formed in vivo under conditions of antibody excess were rapidly cleared from the circulation of both normal and leukaemic Hooded rats. In HSA-immune rats most of the 125I-HSA present in the blood was found to be cell-bound, but a proportion was present as ci...

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Autores principales: Shepherd, P. S., Pendry, R. A., Dean, C. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010261/
https://www.ncbi.nlm.nih.gov/pubmed/7387854
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author Shepherd, P. S.
Pendry, R. A.
Dean, C. J.
author_facet Shepherd, P. S.
Pendry, R. A.
Dean, C. J.
author_sort Shepherd, P. S.
collection PubMed
description Immune complexes of 125I-HSA-rat anti-HSA formed in vivo under conditions of antibody excess were rapidly cleared from the circulation of both normal and leukaemic Hooded rats. In HSA-immune rats most of the 125I-HSA present in the blood was found to be cell-bound, but a proportion was present as circulating immune complexes that could be precipitated from plasma by 2.5% polyethylene glycol. There was no evidence that clearance of a soluble antigen was impaired in leukaemic animals.
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spelling pubmed-20102612009-09-10 Clearance of immune complexes formed in normal and leukaemic rats. Shepherd, P. S. Pendry, R. A. Dean, C. J. Br J Cancer Research Article Immune complexes of 125I-HSA-rat anti-HSA formed in vivo under conditions of antibody excess were rapidly cleared from the circulation of both normal and leukaemic Hooded rats. In HSA-immune rats most of the 125I-HSA present in the blood was found to be cell-bound, but a proportion was present as circulating immune complexes that could be precipitated from plasma by 2.5% polyethylene glycol. There was no evidence that clearance of a soluble antigen was impaired in leukaemic animals. Nature Publishing Group 1980-04 /pmc/articles/PMC2010261/ /pubmed/7387854 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shepherd, P. S.
Pendry, R. A.
Dean, C. J.
Clearance of immune complexes formed in normal and leukaemic rats.
title Clearance of immune complexes formed in normal and leukaemic rats.
title_full Clearance of immune complexes formed in normal and leukaemic rats.
title_fullStr Clearance of immune complexes formed in normal and leukaemic rats.
title_full_unstemmed Clearance of immune complexes formed in normal and leukaemic rats.
title_short Clearance of immune complexes formed in normal and leukaemic rats.
title_sort clearance of immune complexes formed in normal and leukaemic rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010261/
https://www.ncbi.nlm.nih.gov/pubmed/7387854
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