Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.

cis-Dichlorodiammineplatinum(II) (cis-Pt(II) can act as a radiosensitizer of hypoxic mammalian cells in vitro. Used in combination with misonidazole the level of sensitization achieved is greater than that seen with either drug alone, and it is suggested that these compounds sensitize by independent...

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Autores principales: Stratford, I. J., Williamson, C., Adams, G. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010266/
https://www.ncbi.nlm.nih.gov/pubmed/7190019
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author Stratford, I. J.
Williamson, C.
Adams, G. E.
author_facet Stratford, I. J.
Williamson, C.
Adams, G. E.
author_sort Stratford, I. J.
collection PubMed
description cis-Dichlorodiammineplatinum(II) (cis-Pt(II) can act as a radiosensitizer of hypoxic mammalian cells in vitro. Used in combination with misonidazole the level of sensitization achieved is greater than that seen with either drug alone, and it is suggested that these compounds sensitize by independent mechanisms. For cells held at 37 degrees C, cis-Pt(II) shows much greater toxicity to hypoxic cells than to aerobic cells. In combination with misonidazole, no additional cytotoxic effect is shown towards aerobic cells than that seen for cis-Pt(II) alone. However, there is additional killing of hypoxic cells when they are treated with both drugs.
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spelling pubmed-20102662009-09-10 Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro. Stratford, I. J. Williamson, C. Adams, G. E. Br J Cancer Research Article cis-Dichlorodiammineplatinum(II) (cis-Pt(II) can act as a radiosensitizer of hypoxic mammalian cells in vitro. Used in combination with misonidazole the level of sensitization achieved is greater than that seen with either drug alone, and it is suggested that these compounds sensitize by independent mechanisms. For cells held at 37 degrees C, cis-Pt(II) shows much greater toxicity to hypoxic cells than to aerobic cells. In combination with misonidazole, no additional cytotoxic effect is shown towards aerobic cells than that seen for cis-Pt(II) alone. However, there is additional killing of hypoxic cells when they are treated with both drugs. Nature Publishing Group 1980-04 /pmc/articles/PMC2010266/ /pubmed/7190019 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Stratford, I. J.
Williamson, C.
Adams, G. E.
Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
title Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
title_full Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
title_fullStr Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
title_full_unstemmed Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
title_short Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
title_sort combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010266/
https://www.ncbi.nlm.nih.gov/pubmed/7190019
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