Serum sialic acid and CEA concentrations in human breast cancer.

The concentration of bound sialic acid in the sera of 56 normal subjects and 65 subjects with breast cancer was measured, in order to determine (1) whether serum sialic acid concentrations are raised in breast cancer and (2) whether the concentration of sialic acid in serum reflects tumour stage. Th...

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Autores principales: Hogan-Ryan, A., Fennelly, J. J., Jones, M., Cantwell, B., Duffy, M. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010272/
https://www.ncbi.nlm.nih.gov/pubmed/7387856
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author Hogan-Ryan, A.
Fennelly, J. J.
Jones, M.
Cantwell, B.
Duffy, M. J.
author_facet Hogan-Ryan, A.
Fennelly, J. J.
Jones, M.
Cantwell, B.
Duffy, M. J.
author_sort Hogan-Ryan, A.
collection PubMed
description The concentration of bound sialic acid in the sera of 56 normal subjects and 65 subjects with breast cancer was measured, in order to determine (1) whether serum sialic acid concentrations are raised in breast cancer and (2) whether the concentration of sialic acid in serum reflects tumour stage. The amount of sialic acid in serum was compared to serum carcinoembryonic antigen (CEA) values. Urinary hydroxyproline and serum alkaline phosphatase concentrations were used as indicators of bone and liver involvement. Erythrocyte sedimentation rate (ESR) was also measured. Significantly elevated serum sialic acid concentrations were found in breast cancer, and showed correlation with tumour stage. Serum sialic acid values did not correlate with CEA values. The results suggest that measurement of serum sialic acid concentrations may be of adjunctive value in assessing tumour stage.
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spelling pubmed-20102722009-09-10 Serum sialic acid and CEA concentrations in human breast cancer. Hogan-Ryan, A. Fennelly, J. J. Jones, M. Cantwell, B. Duffy, M. J. Br J Cancer Research Article The concentration of bound sialic acid in the sera of 56 normal subjects and 65 subjects with breast cancer was measured, in order to determine (1) whether serum sialic acid concentrations are raised in breast cancer and (2) whether the concentration of sialic acid in serum reflects tumour stage. The amount of sialic acid in serum was compared to serum carcinoembryonic antigen (CEA) values. Urinary hydroxyproline and serum alkaline phosphatase concentrations were used as indicators of bone and liver involvement. Erythrocyte sedimentation rate (ESR) was also measured. Significantly elevated serum sialic acid concentrations were found in breast cancer, and showed correlation with tumour stage. Serum sialic acid values did not correlate with CEA values. The results suggest that measurement of serum sialic acid concentrations may be of adjunctive value in assessing tumour stage. Nature Publishing Group 1980-04 /pmc/articles/PMC2010272/ /pubmed/7387856 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hogan-Ryan, A.
Fennelly, J. J.
Jones, M.
Cantwell, B.
Duffy, M. J.
Serum sialic acid and CEA concentrations in human breast cancer.
title Serum sialic acid and CEA concentrations in human breast cancer.
title_full Serum sialic acid and CEA concentrations in human breast cancer.
title_fullStr Serum sialic acid and CEA concentrations in human breast cancer.
title_full_unstemmed Serum sialic acid and CEA concentrations in human breast cancer.
title_short Serum sialic acid and CEA concentrations in human breast cancer.
title_sort serum sialic acid and cea concentrations in human breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010272/
https://www.ncbi.nlm.nih.gov/pubmed/7387856
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