Interaction of human serum albumin with anticancer agents in vitro.

The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diam...

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Autores principales: Takahashi, I., Ohnuma, T., Kavy, S., Bhardwaj, S., Holland, J. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010273/
https://www.ncbi.nlm.nih.gov/pubmed/7190020
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author Takahashi, I.
Ohnuma, T.
Kavy, S.
Bhardwaj, S.
Holland, J. F.
author_facet Takahashi, I.
Ohnuma, T.
Kavy, S.
Bhardwaj, S.
Holland, J. F.
author_sort Takahashi, I.
collection PubMed
description The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diamminedichloroplatinum (II), 4'-(9-acridinylamino)methanesulphon-m-anisidide, neocarzinostatin, nitrogen mustard, adriamycin, daunorubicin and mitomycin C--drugs whose biological activities are reduced in the presence of HA. The biological activities of Type II drugs (cytosine arabinoside, fluorouracil and actinomycin D) are not influenced by HA. The biological activities of Type III drugs (bleomycin, vincristine and vinblastine) are increased in the presence of HA. These results indicate that serum HA interferes in vitro with certain anticancer agents in terms of biological activity and, probably, clinical effectiveness. HA-drug interaction may be a major factor governing the pharmacology of Type I anticancer agents in man.
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spelling pubmed-20102732009-09-10 Interaction of human serum albumin with anticancer agents in vitro. Takahashi, I. Ohnuma, T. Kavy, S. Bhardwaj, S. Holland, J. F. Br J Cancer Research Article The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diamminedichloroplatinum (II), 4'-(9-acridinylamino)methanesulphon-m-anisidide, neocarzinostatin, nitrogen mustard, adriamycin, daunorubicin and mitomycin C--drugs whose biological activities are reduced in the presence of HA. The biological activities of Type II drugs (cytosine arabinoside, fluorouracil and actinomycin D) are not influenced by HA. The biological activities of Type III drugs (bleomycin, vincristine and vinblastine) are increased in the presence of HA. These results indicate that serum HA interferes in vitro with certain anticancer agents in terms of biological activity and, probably, clinical effectiveness. HA-drug interaction may be a major factor governing the pharmacology of Type I anticancer agents in man. Nature Publishing Group 1980-04 /pmc/articles/PMC2010273/ /pubmed/7190020 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Takahashi, I.
Ohnuma, T.
Kavy, S.
Bhardwaj, S.
Holland, J. F.
Interaction of human serum albumin with anticancer agents in vitro.
title Interaction of human serum albumin with anticancer agents in vitro.
title_full Interaction of human serum albumin with anticancer agents in vitro.
title_fullStr Interaction of human serum albumin with anticancer agents in vitro.
title_full_unstemmed Interaction of human serum albumin with anticancer agents in vitro.
title_short Interaction of human serum albumin with anticancer agents in vitro.
title_sort interaction of human serum albumin with anticancer agents in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010273/
https://www.ncbi.nlm.nih.gov/pubmed/7190020
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