Monoclonal immunoglobulin light chains in urine of patients with lymphoma.

Fourteen of 31 patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia had a monoclonal immunoglobulin light chain detectable in their urine. These chains are believed to be synthesized by the B lymphoid cells comprising the tumour. Upon comparing the different cases, the occurren...

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Autores principales: Pierson, J., Darley, T., Stevenson, G. T., Virji, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010299/
https://www.ncbi.nlm.nih.gov/pubmed/6775652
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author Pierson, J.
Darley, T.
Stevenson, G. T.
Virji, M.
author_facet Pierson, J.
Darley, T.
Stevenson, G. T.
Virji, M.
author_sort Pierson, J.
collection PubMed
description Fourteen of 31 patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia had a monoclonal immunoglobulin light chain detectable in their urine. These chains are believed to be synthesized by the B lymphoid cells comprising the tumour. Upon comparing the different cases, the occurrence and amount of monoclonal light chain showed no dependence upon the extent of tumour, the presence of leukaemic component, or exposure to cytotoxic therapy. The method of detection involved purifying the urinary light chains by immunosorption, and examining their electrophoretic distributions so as to distinguish between the homogeneous monoclonal chains and their heterogeneous normal analogues. IMAGES:
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spelling pubmed-20102992009-09-10 Monoclonal immunoglobulin light chains in urine of patients with lymphoma. Pierson, J. Darley, T. Stevenson, G. T. Virji, M. Br J Cancer Research Article Fourteen of 31 patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia had a monoclonal immunoglobulin light chain detectable in their urine. These chains are believed to be synthesized by the B lymphoid cells comprising the tumour. Upon comparing the different cases, the occurrence and amount of monoclonal light chain showed no dependence upon the extent of tumour, the presence of leukaemic component, or exposure to cytotoxic therapy. The method of detection involved purifying the urinary light chains by immunosorption, and examining their electrophoretic distributions so as to distinguish between the homogeneous monoclonal chains and their heterogeneous normal analogues. IMAGES: Nature Publishing Group 1980-05 /pmc/articles/PMC2010299/ /pubmed/6775652 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pierson, J.
Darley, T.
Stevenson, G. T.
Virji, M.
Monoclonal immunoglobulin light chains in urine of patients with lymphoma.
title Monoclonal immunoglobulin light chains in urine of patients with lymphoma.
title_full Monoclonal immunoglobulin light chains in urine of patients with lymphoma.
title_fullStr Monoclonal immunoglobulin light chains in urine of patients with lymphoma.
title_full_unstemmed Monoclonal immunoglobulin light chains in urine of patients with lymphoma.
title_short Monoclonal immunoglobulin light chains in urine of patients with lymphoma.
title_sort monoclonal immunoglobulin light chains in urine of patients with lymphoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010299/
https://www.ncbi.nlm.nih.gov/pubmed/6775652
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AT virjim monoclonalimmunoglobulinlightchainsinurineofpatientswithlymphoma

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