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Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma.
Reported elevations of total serum sialic acid may be a result of shed tumour-related membrane sialyglycoprotein and/or concurrent elevation of non-specific, acute-phase reactant sialoglycoprotein. To clarify further the specificity and sensitivity of serum sialic acid monitoring, analyses of sialic...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1980
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010328/ https://www.ncbi.nlm.nih.gov/pubmed/6158966 |
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author | Silver, H. K. Karim, K. A. Salinas, F. A. |
author_facet | Silver, H. K. Karim, K. A. Salinas, F. A. |
author_sort | Silver, H. K. |
collection | PubMed |
description | Reported elevations of total serum sialic acid may be a result of shed tumour-related membrane sialyglycoprotein and/or concurrent elevation of non-specific, acute-phase reactant sialoglycoprotein. To clarify further the specificity and sensitivity of serum sialic acid monitoring, analyses of sialic acid by the thiobarbituric acid method and acute-phase reactants by radial immunodiffusion were made using the same malignant melanoma patients' sera. Preliminary studies of IgG, IgA, IgM, ceruloplasmin and C-reactive protein suggested that these would not be valuable monitors of tumour burden. Single serum samples from 59 melanoma patients and age- and sex-matched controls were further examined for sialic acid, alpha 1-acid glycoprotein, alpha 1-antitrypsin, haptoglobin, and alpha 2-macroglobulin. Patients were grouped according to tumour burden. In pairwise statistical tests, differences between groups tended to be greater for sialic acid than for acute-phase reactants. On discriminant analysis , sialic acid was clearly the most significant single discriminator between groups, with an F statistic of P < 0.00005. Although alpha 1-acid glycoprotein was quite strongly correlated with sialic acid, it was not such a good discriminator and did not add significantly to the predictive power of sialic acid alone. |
format | Text |
id | pubmed-2010328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1980 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20103282009-09-10 Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. Silver, H. K. Karim, K. A. Salinas, F. A. Br J Cancer Research Article Reported elevations of total serum sialic acid may be a result of shed tumour-related membrane sialyglycoprotein and/or concurrent elevation of non-specific, acute-phase reactant sialoglycoprotein. To clarify further the specificity and sensitivity of serum sialic acid monitoring, analyses of sialic acid by the thiobarbituric acid method and acute-phase reactants by radial immunodiffusion were made using the same malignant melanoma patients' sera. Preliminary studies of IgG, IgA, IgM, ceruloplasmin and C-reactive protein suggested that these would not be valuable monitors of tumour burden. Single serum samples from 59 melanoma patients and age- and sex-matched controls were further examined for sialic acid, alpha 1-acid glycoprotein, alpha 1-antitrypsin, haptoglobin, and alpha 2-macroglobulin. Patients were grouped according to tumour burden. In pairwise statistical tests, differences between groups tended to be greater for sialic acid than for acute-phase reactants. On discriminant analysis , sialic acid was clearly the most significant single discriminator between groups, with an F statistic of P < 0.00005. Although alpha 1-acid glycoprotein was quite strongly correlated with sialic acid, it was not such a good discriminator and did not add significantly to the predictive power of sialic acid alone. Nature Publishing Group 1980-05 /pmc/articles/PMC2010328/ /pubmed/6158966 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Silver, H. K. Karim, K. A. Salinas, F. A. Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. |
title | Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. |
title_full | Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. |
title_fullStr | Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. |
title_full_unstemmed | Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. |
title_short | Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. |
title_sort | relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010328/ https://www.ncbi.nlm.nih.gov/pubmed/6158966 |
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