Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.

The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equati...

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Autor principal: Eichholtz-Wirth, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010346/
https://www.ncbi.nlm.nih.gov/pubmed/7426313
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author Eichholtz-Wirth, H.
author_facet Eichholtz-Wirth, H.
author_sort Eichholtz-Wirth, H.
collection PubMed
description The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equation: SF=e-ktc. By determining the intracellular drug concentration at various exposures, it could be shown that absorbed dose is not proportional to exposure dose.
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spelling pubmed-20103462009-09-10 Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro. Eichholtz-Wirth, H. Br J Cancer Research Article The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equation: SF=e-ktc. By determining the intracellular drug concentration at various exposures, it could be shown that absorbed dose is not proportional to exposure dose. Nature Publishing Group 1980-06 /pmc/articles/PMC2010346/ /pubmed/7426313 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Eichholtz-Wirth, H.
Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
title Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
title_full Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
title_fullStr Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
title_full_unstemmed Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
title_short Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
title_sort dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010346/
https://www.ncbi.nlm.nih.gov/pubmed/7426313
work_keys_str_mv AT eichholtzwirthh dependenceofthecytostaticeffectofadriamycinondrugconcenrationandexposuretimeinvitro

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