A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.

Intact cells of various human tumours and tumour cell lines, and acid extracts of various human tumours and normal tissues, each of which react with the lymphocytes of cancer patients as detected by the macrophage electrophoretic mobility (MEM) test, have been subjected to proteolysis. Activity was...

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Detalles Bibliográficos
Autores principales: Dickinson, J. P., McDermott, J. R., Smith, J. K., Caspary, E. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010373/
https://www.ncbi.nlm.nih.gov/pubmed/6158971
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author Dickinson, J. P.
McDermott, J. R.
Smith, J. K.
Caspary, E. A.
author_facet Dickinson, J. P.
McDermott, J. R.
Smith, J. K.
Caspary, E. A.
author_sort Dickinson, J. P.
collection PubMed
description Intact cells of various human tumours and tumour cell lines, and acid extracts of various human tumours and normal tissues, each of which react with the lymphocytes of cancer patients as detected by the macrophage electrophoretic mobility (MEM) test, have been subjected to proteolysis. Activity was destroyed by some enzymes, and the apparent molecular size of the active material was reduced by others. An active low-mol.-wt fragment has been partially purified from papain digests of several tumours. Peptides with normal tissue and tumour-characteristic activities have been separated chromatographically from tryptic digests of tumour extracts.
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spelling pubmed-20103732009-09-10 A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant. Dickinson, J. P. McDermott, J. R. Smith, J. K. Caspary, E. A. Br J Cancer Research Article Intact cells of various human tumours and tumour cell lines, and acid extracts of various human tumours and normal tissues, each of which react with the lymphocytes of cancer patients as detected by the macrophage electrophoretic mobility (MEM) test, have been subjected to proteolysis. Activity was destroyed by some enzymes, and the apparent molecular size of the active material was reduced by others. An active low-mol.-wt fragment has been partially purified from papain digests of several tumours. Peptides with normal tissue and tumour-characteristic activities have been separated chromatographically from tryptic digests of tumour extracts. Nature Publishing Group 1980-08 /pmc/articles/PMC2010373/ /pubmed/6158971 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dickinson, J. P.
McDermott, J. R.
Smith, J. K.
Caspary, E. A.
A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.
title A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.
title_full A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.
title_fullStr A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.
title_full_unstemmed A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.
title_short A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.
title_sort common tumour-specific antigen: iii. preparation of small fragments incorporating the cell-sensitizing determinant.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010373/
https://www.ncbi.nlm.nih.gov/pubmed/6158971
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