Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.

A randomized trial is reported which evaluates the effect of early diagnostic splenectomy on the prognosis of patients with Hodgkin's disease (HD) and uncertain prognosis. This was started in January 1973 and concluded in April 1979. Sixty-seven patients were entered in the study and 31 were ra...

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Autores principales: Askergren, J., Björkholm, M., Holm, G., Johansson, B., Mellstedt, H., Sundblad, R., Söderberg, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010376/
https://www.ncbi.nlm.nih.gov/pubmed/7426335
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author Askergren, J.
Björkholm, M.
Holm, G.
Johansson, B.
Mellstedt, H.
Sundblad, R.
Söderberg, G.
author_facet Askergren, J.
Björkholm, M.
Holm, G.
Johansson, B.
Mellstedt, H.
Sundblad, R.
Söderberg, G.
author_sort Askergren, J.
collection PubMed
description A randomized trial is reported which evaluates the effect of early diagnostic splenectomy on the prognosis of patients with Hodgkin's disease (HD) and uncertain prognosis. This was started in January 1973 and concluded in April 1979. Sixty-seven patients were entered in the study and 31 were randomized for splenectomy. All patients except 2 received total nodal irradiation, excluding the splenic and hepatic areas. After 40 months' observation there was no difference between the groups in respect of survival and the number of recurrences. However, relapses occurred earlier in the splenectomized patients. Pneumococcal septicaemia was recorded in 2 splenectomized patients. It is concluded that prognosis is not improved by diagnostic splenectomy in HD patients with uncertain prognosis and treated with total nodal irradiation.
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spelling pubmed-20103762009-09-10 Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial. Askergren, J. Björkholm, M. Holm, G. Johansson, B. Mellstedt, H. Sundblad, R. Söderberg, G. Br J Cancer Research Article A randomized trial is reported which evaluates the effect of early diagnostic splenectomy on the prognosis of patients with Hodgkin's disease (HD) and uncertain prognosis. This was started in January 1973 and concluded in April 1979. Sixty-seven patients were entered in the study and 31 were randomized for splenectomy. All patients except 2 received total nodal irradiation, excluding the splenic and hepatic areas. After 40 months' observation there was no difference between the groups in respect of survival and the number of recurrences. However, relapses occurred earlier in the splenectomized patients. Pneumococcal septicaemia was recorded in 2 splenectomized patients. It is concluded that prognosis is not improved by diagnostic splenectomy in HD patients with uncertain prognosis and treated with total nodal irradiation. Nature Publishing Group 1980-08 /pmc/articles/PMC2010376/ /pubmed/7426335 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Askergren, J.
Björkholm, M.
Holm, G.
Johansson, B.
Mellstedt, H.
Sundblad, R.
Söderberg, G.
Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.
title Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.
title_full Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.
title_fullStr Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.
title_full_unstemmed Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.
title_short Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.
title_sort prognostic effect of early diagnostic splenectomy in hodgkin's disease: a randomized trial.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010376/
https://www.ncbi.nlm.nih.gov/pubmed/7426335
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