Collagenase immunolocalization studies of cutaneous secondary melanomas.

Immunoreactive collagenase has been demonstrated in 5/14 specimens of cutaneous secondary melanomas. In contrast, very little enzyme was seen in 10 specimens of normal human skin. All specimens were fixed within minutes of excision. These findings support the hypothesis that collagenase facilitates...

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Detalles Bibliográficos
Autores principales: Woolley, D. E., Grafton, C. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010383/
https://www.ncbi.nlm.nih.gov/pubmed/6252926
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author Woolley, D. E.
Grafton, C. A.
author_facet Woolley, D. E.
Grafton, C. A.
author_sort Woolley, D. E.
collection PubMed
description Immunoreactive collagenase has been demonstrated in 5/14 specimens of cutaneous secondary melanomas. In contrast, very little enzyme was seen in 10 specimens of normal human skin. All specimens were fixed within minutes of excision. These findings support the hypothesis that collagenase facilitates connective-tissue breakdown which is associated with tumour invasiveness and metastatic spread. IMAGES:
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spelling pubmed-20103832009-09-10 Collagenase immunolocalization studies of cutaneous secondary melanomas. Woolley, D. E. Grafton, C. A. Br J Cancer Research Article Immunoreactive collagenase has been demonstrated in 5/14 specimens of cutaneous secondary melanomas. In contrast, very little enzyme was seen in 10 specimens of normal human skin. All specimens were fixed within minutes of excision. These findings support the hypothesis that collagenase facilitates connective-tissue breakdown which is associated with tumour invasiveness and metastatic spread. IMAGES: Nature Publishing Group 1980-08 /pmc/articles/PMC2010383/ /pubmed/6252926 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Woolley, D. E.
Grafton, C. A.
Collagenase immunolocalization studies of cutaneous secondary melanomas.
title Collagenase immunolocalization studies of cutaneous secondary melanomas.
title_full Collagenase immunolocalization studies of cutaneous secondary melanomas.
title_fullStr Collagenase immunolocalization studies of cutaneous secondary melanomas.
title_full_unstemmed Collagenase immunolocalization studies of cutaneous secondary melanomas.
title_short Collagenase immunolocalization studies of cutaneous secondary melanomas.
title_sort collagenase immunolocalization studies of cutaneous secondary melanomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010383/
https://www.ncbi.nlm.nih.gov/pubmed/6252926
work_keys_str_mv AT woolleyde collagenaseimmunolocalizationstudiesofcutaneoussecondarymelanomas
AT graftonca collagenaseimmunolocalizationstudiesofcutaneoussecondarymelanomas

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