Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.

Mammalian cells (V79-379A) in suspension culture rendered chronically hypoxic showed greater resistance to Adriamycin than exponentially growing aerobic cells. Resistance to Adriamycin increased as a function of the time cells were held under hypoxic conditions, with maximal resistance after 6 h. Ch...

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Detalles Bibliográficos
Autores principales: Smith, E., Stratford, I. J., Adams, G. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010438/
https://www.ncbi.nlm.nih.gov/pubmed/7437289
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author Smith, E.
Stratford, I. J.
Adams, G. E.
author_facet Smith, E.
Stratford, I. J.
Adams, G. E.
author_sort Smith, E.
collection PubMed
description Mammalian cells (V79-379A) in suspension culture rendered chronically hypoxic showed greater resistance to Adriamycin than exponentially growing aerobic cells. Resistance to Adriamycin increased as a function of the time cells were held under hypoxic conditions, with maximal resistance after 6 h. Chronically hypoxic cells retained their resistance when reoxygenated, and did not return to their original sensitivity until they had been in air for 24 h. Uptake of Adriamycin was similar for chronically hypoxic and exponentially growing aerobic cells, but much more than for plateau-phase cells. These findings suggest that chronically hypoxic cells in tumours may be resistant to this drug.
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spelling pubmed-20104382009-09-10 Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro. Smith, E. Stratford, I. J. Adams, G. E. Br J Cancer Research Article Mammalian cells (V79-379A) in suspension culture rendered chronically hypoxic showed greater resistance to Adriamycin than exponentially growing aerobic cells. Resistance to Adriamycin increased as a function of the time cells were held under hypoxic conditions, with maximal resistance after 6 h. Chronically hypoxic cells retained their resistance when reoxygenated, and did not return to their original sensitivity until they had been in air for 24 h. Uptake of Adriamycin was similar for chronically hypoxic and exponentially growing aerobic cells, but much more than for plateau-phase cells. These findings suggest that chronically hypoxic cells in tumours may be resistant to this drug. Nature Publishing Group 1980-10 /pmc/articles/PMC2010438/ /pubmed/7437289 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Smith, E.
Stratford, I. J.
Adams, G. E.
Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.
title Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.
title_full Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.
title_fullStr Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.
title_full_unstemmed Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.
title_short Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.
title_sort cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster v79 cells in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010438/
https://www.ncbi.nlm.nih.gov/pubmed/7437289
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AT adamsge cytotoxicityofadriamycinonaerobicandhypoxicchinesehamsterv79cellsinvitro

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