Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.

The effect of lymphocytes from normal mice on the growth of a syngeneic, radiation-induced, T-cell-derived lymphoma was investigated. Thymus and spleen cells enhanced the growth of admixed lymphoma cells in a reproducible manner. Growth enhancement was manifested by the earlier appearance and higher...

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Detalles Bibliográficos
Autores principales: Gabizon, A., Trainin, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010444/
https://www.ncbi.nlm.nih.gov/pubmed/6969087
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author Gabizon, A.
Trainin, N.
author_facet Gabizon, A.
Trainin, N.
author_sort Gabizon, A.
collection PubMed
description The effect of lymphocytes from normal mice on the growth of a syngeneic, radiation-induced, T-cell-derived lymphoma was investigated. Thymus and spleen cells enhanced the growth of admixed lymphoma cells in a reproducible manner. Growth enhancement was manifested by the earlier appearance and higher final incidence of tumours. Lymphocytes also enhanced the growth of radiation-damaged lymphoma cells. The enhancing activity of spleen cells was predominantly a property of T cells, since it was abolished by treatment with anti-theta serum plus complement and significantly less in spleen cells of nude mice. Tumour-enhancing thymocytes seem to belong to the immature thymic subpopulation, as indicated by their binding to peanut agglutinin.
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spelling pubmed-20104442009-09-10 Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice. Gabizon, A. Trainin, N. Br J Cancer Research Article The effect of lymphocytes from normal mice on the growth of a syngeneic, radiation-induced, T-cell-derived lymphoma was investigated. Thymus and spleen cells enhanced the growth of admixed lymphoma cells in a reproducible manner. Growth enhancement was manifested by the earlier appearance and higher final incidence of tumours. Lymphocytes also enhanced the growth of radiation-damaged lymphoma cells. The enhancing activity of spleen cells was predominantly a property of T cells, since it was abolished by treatment with anti-theta serum plus complement and significantly less in spleen cells of nude mice. Tumour-enhancing thymocytes seem to belong to the immature thymic subpopulation, as indicated by their binding to peanut agglutinin. Nature Publishing Group 1980-10 /pmc/articles/PMC2010444/ /pubmed/6969087 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gabizon, A.
Trainin, N.
Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.
title Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.
title_full Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.
title_fullStr Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.
title_full_unstemmed Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.
title_short Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.
title_sort enhancement of growth of a radiation-induced lymphoma by t cells from normal mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010444/
https://www.ncbi.nlm.nih.gov/pubmed/6969087
work_keys_str_mv AT gabizona enhancementofgrowthofaradiationinducedlymphomabytcellsfromnormalmice
AT traininn enhancementofgrowthofaradiationinducedlymphomabytcellsfromnormalmice

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