Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.

The relationship between ageing and transformation has been investigated by a serial study of the changes in cell-surface morphology as normal and carcinogen-treated cells progressed in culture. A progressive increase in the density of cell surface microvilli occurred in association with the adoptio...

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Autores principales: Harrison, C. J., Connell, J. R., Allen, T. D., Ockey, C. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010466/
https://www.ncbi.nlm.nih.gov/pubmed/6775654
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author Harrison, C. J.
Connell, J. R.
Allen, T. D.
Ockey, C. H.
author_facet Harrison, C. J.
Connell, J. R.
Allen, T. D.
Ockey, C. H.
author_sort Harrison, C. J.
collection PubMed
description The relationship between ageing and transformation has been investigated by a serial study of the changes in cell-surface morphology as normal and carcinogen-treated cells progressed in culture. A progressive increase in the density of cell surface microvilli occurred in association with the adoption of a more rounded profile and concomitant increase in the rate of cell detachment. These changes occurred earlier after carcinogen treatment, which appeared to indicate a carcinogen-induced acceleration of ageing. The alterations have also been described as characteristic of the transformed state. The observations suggest that the expression of in vitro transformation may be the result of continuous selection from a population with genetic instability and variable morphology. IMAGES:
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spelling pubmed-20104662009-09-10 Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells. Harrison, C. J. Connell, J. R. Allen, T. D. Ockey, C. H. Br J Cancer Research Article The relationship between ageing and transformation has been investigated by a serial study of the changes in cell-surface morphology as normal and carcinogen-treated cells progressed in culture. A progressive increase in the density of cell surface microvilli occurred in association with the adoption of a more rounded profile and concomitant increase in the rate of cell detachment. These changes occurred earlier after carcinogen treatment, which appeared to indicate a carcinogen-induced acceleration of ageing. The alterations have also been described as characteristic of the transformed state. The observations suggest that the expression of in vitro transformation may be the result of continuous selection from a population with genetic instability and variable morphology. IMAGES: Nature Publishing Group 1980-07 /pmc/articles/PMC2010466/ /pubmed/6775654 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Harrison, C. J.
Connell, J. R.
Allen, T. D.
Ockey, C. H.
Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.
title Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.
title_full Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.
title_fullStr Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.
title_full_unstemmed Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.
title_short Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.
title_sort changes in surface morphology associated with ageing and carcinogen treatment of chinese hamster lung cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010466/
https://www.ncbi.nlm.nih.gov/pubmed/6775654
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AT allentd changesinsurfacemorphologyassociatedwithageingandcarcinogentreatmentofchinesehamsterlungcells
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