DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.

T1 relaxation values of rat liver and spleen tissue have been measured over a 6-month period whilst feeding with p-dimethyl-aminoazobenzene (DAB). Measurements of tissue water and iron content have also been made. A small rise in liver T1 value during the early stages of DAB feeding, from a control...

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Detalles Bibliográficos
Autores principales: Ling, C. R., Foster, M. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010476/
https://www.ncbi.nlm.nih.gov/pubmed/6775655
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author Ling, C. R.
Foster, M. A.
author_facet Ling, C. R.
Foster, M. A.
author_sort Ling, C. R.
collection PubMed
description T1 relaxation values of rat liver and spleen tissue have been measured over a 6-month period whilst feeding with p-dimethyl-aminoazobenzene (DAB). Measurements of tissue water and iron content have also been made. A small rise in liver T1 value during the early stages of DAB feeding, from a control value of 296 +/- 12 ms to 318 +/- 12 ms after 3 weeks, probably reflected toxic reaction to the diet rather than preneoplastic changes. Spleen T1 value showed a considerable decrease over this same period, from a mean control value of 505 +/- 14 ms to 394 +/- 21 ms after 3 weeks on the diet. The possible origins of this change are discussed.
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spelling pubmed-20104762009-09-10 DAB-induced changes in NMR relaxation times, water and iron content of rat tissue. Ling, C. R. Foster, M. A. Br J Cancer Research Article T1 relaxation values of rat liver and spleen tissue have been measured over a 6-month period whilst feeding with p-dimethyl-aminoazobenzene (DAB). Measurements of tissue water and iron content have also been made. A small rise in liver T1 value during the early stages of DAB feeding, from a control value of 296 +/- 12 ms to 318 +/- 12 ms after 3 weeks, probably reflected toxic reaction to the diet rather than preneoplastic changes. Spleen T1 value showed a considerable decrease over this same period, from a mean control value of 505 +/- 14 ms to 394 +/- 21 ms after 3 weeks on the diet. The possible origins of this change are discussed. Nature Publishing Group 1980-07 /pmc/articles/PMC2010476/ /pubmed/6775655 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ling, C. R.
Foster, M. A.
DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.
title DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.
title_full DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.
title_fullStr DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.
title_full_unstemmed DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.
title_short DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.
title_sort dab-induced changes in nmr relaxation times, water and iron content of rat tissue.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010476/
https://www.ncbi.nlm.nih.gov/pubmed/6775655
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