Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.

We have measured mitotic indices and 3H-thymidine-labelling indices for the colonic epithelial tumours induced in rats by the administration of dimethyl-hydrazine (DMH). The fraction-of-labelled-mitoses (FLM) technique has been used to estimate the duration of the cell-cycle phases. In general, mito...

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Autores principales: Sunter, J. P., Hull, D. L., Appleton, D. R., Watson, A. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1980
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010484/
https://www.ncbi.nlm.nih.gov/pubmed/7426333
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author Sunter, J. P.
Hull, D. L.
Appleton, D. R.
Watson, A. J.
author_facet Sunter, J. P.
Hull, D. L.
Appleton, D. R.
Watson, A. J.
author_sort Sunter, J. P.
collection PubMed
description We have measured mitotic indices and 3H-thymidine-labelling indices for the colonic epithelial tumours induced in rats by the administration of dimethyl-hydrazine (DMH). The fraction-of-labelled-mitoses (FLM) technique has been used to estimate the duration of the cell-cycle phases. In general, mitotic and labelling indices in the tumours are similar to those in the proliferation zone of the normal crypt epithelium; lesions considered to be least well differentiated on histological grounds appear to have the lowest mean labelling index. Benign tumours and the different types of malignant tumours have mean cell-cycle times about half those of the normal mucosa.
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spelling pubmed-20104842009-09-10 Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats. Sunter, J. P. Hull, D. L. Appleton, D. R. Watson, A. J. Br J Cancer Research Article We have measured mitotic indices and 3H-thymidine-labelling indices for the colonic epithelial tumours induced in rats by the administration of dimethyl-hydrazine (DMH). The fraction-of-labelled-mitoses (FLM) technique has been used to estimate the duration of the cell-cycle phases. In general, mitotic and labelling indices in the tumours are similar to those in the proliferation zone of the normal crypt epithelium; lesions considered to be least well differentiated on histological grounds appear to have the lowest mean labelling index. Benign tumours and the different types of malignant tumours have mean cell-cycle times about half those of the normal mucosa. Nature Publishing Group 1980-07 /pmc/articles/PMC2010484/ /pubmed/7426333 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sunter, J. P.
Hull, D. L.
Appleton, D. R.
Watson, A. J.
Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
title Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
title_full Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
title_fullStr Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
title_full_unstemmed Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
title_short Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
title_sort cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010484/
https://www.ncbi.nlm.nih.gov/pubmed/7426333
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