Oral contraceptive use and early abortion as risk factors for breast cancer in young women.

A case-control study was conducted in Los Angeles County, California, of 163 very young breast-cancer cases (all aged 32 or less at diagnosis) to investigate the role, if any, of oral contraceptives (OC) in the development of the disease. OC use before first full-term pregnancy (FFTP) was associated...

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Autores principales: Pike, M. C., Henderson, B. E., Casagrande, J. T., Rosario, I., Gray, G. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010485/
https://www.ncbi.nlm.nih.gov/pubmed/7459241
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author Pike, M. C.
Henderson, B. E.
Casagrande, J. T.
Rosario, I.
Gray, G. E.
author_facet Pike, M. C.
Henderson, B. E.
Casagrande, J. T.
Rosario, I.
Gray, G. E.
author_sort Pike, M. C.
collection PubMed
description A case-control study was conducted in Los Angeles County, California, of 163 very young breast-cancer cases (all aged 32 or less at diagnosis) to investigate the role, if any, of oral contraceptives (OC) in the development of the disease. OC use before first full-term pregnancy (FFTP) was associated with an elevated risk, which increased with duration of OC use (relative risk approximately 2.2 at 6 years of use, P < 0.01). This increased risk could not be explained by other risk factors. OC use after FFTP was not associated with any change in risk. A first-trimester abortion before FFTP, whether spontaneous or induced, was associated with a 2.4-fold increase in breast-cancer risk (P < 0.005).
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spelling pubmed-20104852009-09-10 Oral contraceptive use and early abortion as risk factors for breast cancer in young women. Pike, M. C. Henderson, B. E. Casagrande, J. T. Rosario, I. Gray, G. E. Br J Cancer Research Article A case-control study was conducted in Los Angeles County, California, of 163 very young breast-cancer cases (all aged 32 or less at diagnosis) to investigate the role, if any, of oral contraceptives (OC) in the development of the disease. OC use before first full-term pregnancy (FFTP) was associated with an elevated risk, which increased with duration of OC use (relative risk approximately 2.2 at 6 years of use, P < 0.01). This increased risk could not be explained by other risk factors. OC use after FFTP was not associated with any change in risk. A first-trimester abortion before FFTP, whether spontaneous or induced, was associated with a 2.4-fold increase in breast-cancer risk (P < 0.005). Nature Publishing Group 1981-01 /pmc/articles/PMC2010485/ /pubmed/7459241 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pike, M. C.
Henderson, B. E.
Casagrande, J. T.
Rosario, I.
Gray, G. E.
Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
title Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
title_full Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
title_fullStr Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
title_full_unstemmed Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
title_short Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
title_sort oral contraceptive use and early abortion as risk factors for breast cancer in young women.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010485/
https://www.ncbi.nlm.nih.gov/pubmed/7459241
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