Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.

This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metasta...

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Autores principales: Delaini, F., Giavazzi, R., De Bellis Vitti, G., Alessandri, G., Mantovani, A., Donati, M. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010497/
https://www.ncbi.nlm.nih.gov/pubmed/7459231
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author Delaini, F.
Giavazzi, R.
De Bellis Vitti, G.
Alessandri, G.
Mantovani, A.
Donati, M. B.
author_facet Delaini, F.
Giavazzi, R.
De Bellis Vitti, G.
Alessandri, G.
Mantovani, A.
Donati, M. B.
author_sort Delaini, F.
collection PubMed
description This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.
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spelling pubmed-20104972009-09-10 Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host. Delaini, F. Giavazzi, R. De Bellis Vitti, G. Alessandri, G. Mantovani, A. Donati, M. B. Br J Cancer Research Article This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals. Nature Publishing Group 1981-01 /pmc/articles/PMC2010497/ /pubmed/7459231 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Delaini, F.
Giavazzi, R.
De Bellis Vitti, G.
Alessandri, G.
Mantovani, A.
Donati, M. B.
Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
title Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
title_full Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
title_fullStr Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
title_full_unstemmed Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
title_short Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
title_sort tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010497/
https://www.ncbi.nlm.nih.gov/pubmed/7459231
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