Immune responses to naturally occurring rat sarcomas.

Attempts were made to induce immunity to 5 spontaneous rat sarcomas transplanted into syngeneic recipients. Rats were immunized by surgical removal of growing tumour transplants or by treatment with attenuated tumour, followed by challenge with tumour cells in suspension. Two tumours wee apparently...

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Detalles Bibliográficos
Autores principales: Embleton, M. J., Middle, J. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010502/
https://www.ncbi.nlm.nih.gov/pubmed/7459236
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author Embleton, M. J.
Middle, J. G.
author_facet Embleton, M. J.
Middle, J. G.
author_sort Embleton, M. J.
collection PubMed
description Attempts were made to induce immunity to 5 spontaneous rat sarcomas transplanted into syngeneic recipients. Rats were immunized by surgical removal of growing tumour transplants or by treatment with attenuated tumour, followed by challenge with tumour cells in suspension. Two tumours wee apparently not immunogenic, but a low level of immunity was induced against 2, and weak evidence of immunity was observed with another. Induced immunity was individually specific rather than cross-reactive. It is concluded that, contrary to some reports, some spontaneous animal tumours are immunogenic in the strain of origin.
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spelling pubmed-20105022009-09-10 Immune responses to naturally occurring rat sarcomas. Embleton, M. J. Middle, J. G. Br J Cancer Research Article Attempts were made to induce immunity to 5 spontaneous rat sarcomas transplanted into syngeneic recipients. Rats were immunized by surgical removal of growing tumour transplants or by treatment with attenuated tumour, followed by challenge with tumour cells in suspension. Two tumours wee apparently not immunogenic, but a low level of immunity was induced against 2, and weak evidence of immunity was observed with another. Induced immunity was individually specific rather than cross-reactive. It is concluded that, contrary to some reports, some spontaneous animal tumours are immunogenic in the strain of origin. Nature Publishing Group 1981-01 /pmc/articles/PMC2010502/ /pubmed/7459236 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Embleton, M. J.
Middle, J. G.
Immune responses to naturally occurring rat sarcomas.
title Immune responses to naturally occurring rat sarcomas.
title_full Immune responses to naturally occurring rat sarcomas.
title_fullStr Immune responses to naturally occurring rat sarcomas.
title_full_unstemmed Immune responses to naturally occurring rat sarcomas.
title_short Immune responses to naturally occurring rat sarcomas.
title_sort immune responses to naturally occurring rat sarcomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010502/
https://www.ncbi.nlm.nih.gov/pubmed/7459236
work_keys_str_mv AT embletonmj immuneresponsestonaturallyoccurringratsarcomas
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